Results 111 to 120 of about 4,655,604 (279)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Dual optical frequency comb using a multi-functional PIC based on fully integrated injection locked gain-switched lasers

open access: yesScientific Reports
The authors demonstrate and characterise a versatile photonic integrated circuit (PIC) that could serve as a mutually injection locked optical frequency comb (OFC), a 4-channel optical coherent transmitter or a dual optical frequency comb (DOFC).
Alejandro Rosado   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

An Approach to Nuclear Fusion Utilizing the Dynamics of High-Density Electrons and Neutrals, Part I

open access: yesPlasma
An approach to achieve nuclear fusion utilizing the formation of high densities of electrons and neutrals is described. The abundance of low energy free electrons produces intense electric fields that reduce the Coulomb barrier in nuclear fusion ...
Alfred YiuFai Wong, Chun-Ching Shih
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Information Theoretic Inequalities as Bounds in Superconformal Field Theory

open access: yes, 2017
An information theoretic approach to bounds in superconformal field theories is proposed. It is proved that the supersymmetric R\'enyi entropy $\bar S_\alpha$ is a monotonically decreasing function of $\alpha$ and $(\alpha-1)\bar S_\alpha$ is a concave ...
Zhou, Yang
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Complete mitochondrial genome and phylogenetic analysis of Luciogobius parvulus (Synder, 1909) (Teleostei, Gobiidae) from Korea

open access: yesMitochondrial DNA. Part B. Resources
Luciogobius parvulus (Snyder, 1909) is distributed in restricted areas of Japan and South Korea. Here, we report the first complete mitochondrial genome of this species.
Min-Soo Kim   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Nutritional treatment in patients with cardiovascular diseases, hepatic steatosis and metabolic disorders

open access: yesMìžnarodnij Endokrinologìčnij Žurnal
Background. Cardiovascular diseases remain the leading cause of death in both men and women in ­industrialized countries. They encompass a variety of conditions, including cerebrovascular disease, peripheral arterial disease, atherosclerosis, and deep ...
Fidel Krasniqi   +2 more
doaj   +1 more source

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