Results 41 to 50 of about 1,801,761 (249)
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】探讨种植前基因诊断的临床应用。【方法】对1 例夫妇均为东南亚缺失型α-地中海贫血携带者, 经超排 取卵、卵母细胞单精子显微注射受精及胚胎细胞活检, 吸取的单个卵裂球采用针对α-SEA 基因的gap-PCR 引物和荧光探针用 荧光定量PCR 技术进行诊断, 将诊断为不致病的3 个胚胎进行宫腔内移植。【结果】胚胎移植后7 周B 超诊断单胎妊娠, 18 周羊膜腔穿刺产前诊断证实为不致病胎儿。【结论】应用成熟的显微操作技术进行胚胎细胞活检, 活检的单个卵裂球用荧光 定量PCR 技术进行诊断 ...
李晓红
doaj
AlphaBind, a domain-specific model to predict and optimize antibody–antigen binding affinity
mAbsAntibodies are versatile therapeutic molecules that use combinatorial sequence diversity to cover a vast fitness landscape. Designing optimal antibody sequences, however, remains a major challenge.
Aditya A. Agarwal +14 more
doaj +1 more source
Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy +5 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2001 【目的】研究广东地区人群中β-地中海贫血(β-地贫)杂合子携带α-地中海贫血(α-地贫)1 基因的发生率。 【方法】采用反向点杂交法检测β -地贫基因。采用跨越缺失区断裂点PCR 法检测α-地贫1 基因。【结果】在500 例β-地贫 杂合子DNA 标本中, 共检出43 例合并α-地贫1 , 检出率为8 .6 % 。【结论】广东地区β-地贫杂合子中合并α-地贫1 的发生 率为8.6%, 在遗传咨询和产前诊断过程中需要引起重视。
韩俊英, 曾瑞萍, 胡 彬
doaj
Orphanet journal of rare diseases, 2010 Alpha-thalassaemia is inherited as an autosomal recessive disorder characterised by a microcytic hypochromic anaemia, and a clinical phenotype varying from almost asymptomatic to a lethal haemolytic anaemia.It is probably the most common monogenic gene disorder in the world and is especially frequent in Mediterranean countries, South-East Asia, Africa,
Harteveld, C.L., Higgs, D.R.
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk +9 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neuropsychological complications may impair the qualitative prognosis of patients with pediatric brain tumors. However, multifaceted evaluations cannot be conducted in all patients because they are time consuming and burdensome for patients.
Ami Tabata +9 more
wiley +1 more source
Synthesis, characterization and bio-activity of some new α-aminophosphonates
Bulletin of the Chemical Society of Ethiopia, 2009 A convenient and efficient one-pot reaction has been employed for the synthesis of new -aminophosphonates 4a-4k via Kabachnik-Fields reaction in 65-82 % yields.
A. Balakrishna +4 more
doaj
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson +20 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane +11 more
wiley +1 more source