Results 251 to 260 of about 488,887 (308)

Mapping metabolic reprogramming in lung and breast cancer through integrative bioinformatics. [PDF]

PLoS One
Al-Damook N, Sakkal M, Khair M, Mousa WK, Ghemrawi R.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Interspecies scaling of suprachoroidal drug delivery using ocular geometry and drug physicochemical properties. [PDF]

Sci Rep
Patil MA, Matter BA, Santana C, Kompella UB.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Genomic Analysis of the Halotolerant Hydrocarbon-Oxidizing Bacterium <i>Ectopseudomonas guguanensis</i> G3 from a Petroleum Reservoir. [PDF]

Biology (Basel)
Ershov AP, Tourova TP, Sokolova DS, Semenova EM, Nazina TN.   +4 more
europepmc   +1 more source

Spontaneous Tumor Lysis Syndrome as the Initial Presentation of Chronic Lymphocytic Leukemia: A Case Report. [PDF]

Clin Med Insights Case Rep
Asfaw MD, Mengistie CT, Azale AW, Gebre ME, Assefa AB, Deye FG, Andargie DG.   +6 more
europepmc   +1 more source

Reducing Antimicrobial Resistance in Poultry Carcasses Extends Beyond Farm-Level Interventions. [PDF]

Foods
Indio V, Mekonnen YT, Oliveri C, Rubboli S, Candela M, Seguino A, Serraino A, De Cesare A.   +7 more
europepmc   +1 more source

Changes in the Metabolome of Different Tissues in Response to Streptozotocin Diabetes and Mildronate Exposure: A Metabolomic Assessment. [PDF]

Metabolites
Hauton D, Savic D, Walsby-Tickle J, Tyler D, McCullagh JSO.   +4 more
europepmc   +1 more source

Understanding Lignin Oxidation by a Two-Domain Multicopper Oxidase from <i>Cellvibrio japonicus</i>. [PDF]

Biochemistry
Rese M, van Erven G, Kabel MA, Stepnov AA, Eijsink VGH, Tuveng TR.   +5 more
europepmc   +1 more source