Results 181 to 190 of about 1,209,776 (284)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Gap junctional communication in the intestine affects social feeding behavior via FLP-21 and the NPR-1 mediated signaling pathway. [PDF]

MicroPubl Biol
Calabro L, Peters M.
europepmc   +1 more source

Ｒｏｕｘ－ｅｎ－Ｙ胃旁路术对２型糖尿病大鼠肾脏氧化应激的影响

Zhongshan Daxue xuebao. Yixue kexue ban, 2014
摘 要： 【目的】 研究Ｒｏｕｘ－ｅｎ－Ｙ胃旁路术对２型糖尿病大鼠肾脏氧化应激的影响。【方法】 ４０只ＳＤ大鼠，随机分为正常对照组（ＮＣ，ｎ ＝ ８），糖尿病模型组（３２只），模型组注射链尿菌素（３５ｍｇ／Ｋｇ）成模３０只，将其分为糖尿病对照组（ＤＣ，ｎ＝ ８），假手术组（ＤＳＯ，ｎ ＝ ８），手术组（ＤＯ，ｎ ＝ １４）。检测术前及术后８周空腹血糖（ＦＢＧ）水平，血糖基化终产物（ＡＧＥ）水平，２４ ｈ尿８羟基脱氧鸟苷（８－ＯＨｄＧ）量，尿微量白蛋白（ＭＡＵ）水平；检测术前、术后１、２、４ ...
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Diet Modification Alters Repeated Exposure Ethanol Tolerance Development. [PDF]

MicroPubl Biol
Rodriguez Borrero E, Jimenez Marrero L, Gutierrez Ortiz P, Rivera Alsina A.   +3 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Protocol for the health economic evaluation of nature-based social prescribing against loneliness alongside the RECETAS trials. [PDF]

BMC Public Health
Papon V, Puntscher S, Arvandi M, Jahn B, Litt JS, Coll-Planas L, Masó-Aguado M, Pitkala KH, Laakkonen ML, Roitto HM, Holmerová I, Bartova A, Jones M, Drummond M, Siebert U, Rochau U.   +15 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Developmental and Age-Related RAB-3 phenotypes in a <i>C. elegans</i> Tauopathy Model. [PDF]

MicroPubl Biol
Anderson A, Kim Guisbert K, Borgen M.
europepmc   +1 more source

Hair cortisol: on indicator og HPA activity in relation to environmental perception in New Zealand White rabbits

, 2012
Stebel M, Montillo M, Peric T, Prandi A                 , Comin A, Canavese F   +5 more
core   +1 more source