Results 171 to 180 of about 11,209,230 (308)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Nanostructure-Dependent Signal Intensity in Through-Hole Porous Alumina Membranes for Mass Spectrometry Imaging. [PDF]

Rapid Commun Mass Spectrom
Kotani M, Yanagishita T.
europepmc   +1 more source

Naloxone Does Not Modify the Hemodynamic and Neuroendocrine Effects of Clonidine in Normal Humans

, 1985
Roberto Pedrinelli, Gianpaolo Bernini, Antonio Salvetti   +2 more
openalex   +1 more source

Naloxone and its antagonism of anaesthesia and analgesia [PDF]

, 1984
Mark A. Gillman
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Brazilian nephrologist's knowledge of intradialytic exercise: a national survey. [PDF]

J Bras Nefrol
Cordeiro MDNA, Silva JRD, Policarpo JH, Souza DE, Barbosa JFS, Marinho PÉM.   +5 more
europepmc   +1 more source

Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence: A Randomized Clinical Noninferiority Trial

JAMA psychiatry, 2017
L. Tanum, K. Solli, Zill-E-Huma Latif, J. Benth, Arild Opheim, Kamni Sharma-Haase, P. Krajči, N. Kunøe   +7 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

An Integrated Community Disaster and Climate Resilience Model for rural communities in Zimbabwe. [PDF]

Disasters
Nyahunda L, Nemakonde LD, Khoza S.
europepmc   +1 more source

Respiratory Depressant Effects of Different Doses of Midazolam and Lack of Reversal with Naloxone-A Double-Blind Randomized Study

, 1983
Alain Forster, Denis R. Morel, Marlies Bachmann, M Gemperlé   +3 more
openalex   +1 more source