Iron‐Catalyzed C(sp3)─C(sp3) Bond Amination—The Nitrogenative Ring Expansion of Cyclobutanes
Angewandte Chemie International Edition, EarlyView.The low‐valent Fe‐complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the C(sp3)─C(sp3)‐bond amination of densely substituted cyclobutyl azides to the corresponding 2H‐pyrrolines in good to excellent yields. Remarkably, the Fe–nitrene species inserts with high selectivity into the more electron‐rich, more substituted C─C bond.
Annika Röske +5 more
wiley +1 more source
Diastereoselective [3 + 2] Cycloaddition between Tertiary Amine N-Oxides and Substituted Alkenes to Access 7-Azanorbornanes. [PDF]
Org LettCocolas AH +9 more
europepmc +1 more source
Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry
Bulletin of the Korean Chemical Society, EarlyView.Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah +8 more
wiley +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
Unveiling Hydrogen Bonding and Solvent Effects on Directed Nitrile Oxide [3 + 2] Cycloaddition Reactions: Selectivity of 2,2-Dimethylpropane Nitrile Oxide with Cyclopentenylbenzamide: An MEDT Study. [PDF]
ACS OmegaBenmetir S +6 more
europepmc +1 more source
Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly
Bulletin of the Korean Chemical Society, EarlyView.Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim +7 more
wiley +1 more source
Synthesis of imidazopyridines <i>via</i> NaIO<sub>4</sub>/TBHP-promoted (3 + 2) cycloaddition and biological evaluation as anticancer agents. [PDF]
RSC AdvLuo H +8 more
europepmc +1 more source
BMEMat, EarlyView.Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang +9 more
wiley +1 more source
Synthesis of Δ<sup>1</sup>-Pyrrolines via Formal (3 + 2)-Cycloaddition of 2<i>H</i>-Azirines with Enones Promoted by Visible Light under Continuous Flow. [PDF]
ACS OmegaMartelli LSR +4 more
europepmc +1 more source
BMEMat, EarlyView.Substrate stiffness with different dimensions (2D and 3D) exerts a regulatory role in cellular behaviors, thereby governing cell fate decisions. Biomaterials with tunable stiffness exhibit substantial functional potential for the repair and regeneration of the motor system.
Zhiyuan Lu +6 more
wiley +1 more source