Results 91 to 100 of about 6,274 (134)

Synthesis of chiral difluorinated [6]-gingerol

Tetrahedron, 1996
Abstract Total synthesis of chiral difluorinated [6]-gingerol using key intermediates ( R )-(+)- and ( S )-(−)-ethyl 2,2-difluoro-3-hydroxyoctanoates, obtained via enzymatic resolution with olipase/4S ( Rhizopus japonicus ) is described.
H. Fukuda, M. Tetsu, T. Kitazume
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6-Gingerol Function against Fatigue

Advanced Materials Research, 2011
6-Gingerol was extracted and isolated from fresh ginger (Zingiber officinale Roscoe) to determine its effect on anti-fatigue. The loading forced swimming time, glycogen content in liver and muscle, lactic acid in blood and the content of urea nitrogen in serum were determined from the mice treated orally with 0.30 mg/kg of6-gingerol for 6 weeks.
Xue Song Huang, Ning Peng
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Stages in the biosynthesis of [6]-gingerol in zingiber Officinale

Journal of the Chemical Society, Chemical Communications, 1979
[2-14C,3H,3-3H]Dihydroferulic acid and [1-14C,6-3H]hexanoic acid are shown to be incorporated into (S)-[6]-gingerol in Zingiber officinale, the 3H/14C ratio falling by ½ in the first case but remaining constant in the second; a biogenetic scheme is proposed to accommodate these results, and includes discussion of the late stages of biosynthesis in the ...
Ian Macleod, Donald A. Whiting
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Comparison of the nephroprotective effect of [6]-gingerol and the [6]-gingerol-β-cyclodextrin complex against cisplatin-induced AKI

Naunyn-Schmiedeberg's Archives of Pharmacology
Cisplatin is an antineoplastic agent effective for the treatment of several cancers. However, due to its nephrotoxicity, its use is limited. Acute kidney injury (AKI) induced by cisplatin is caused by inflammation, apoptosis, and oxidative stress in renal tubular cells.
Dayara, de Oliveira Silva, Mikael Almeida, Lima, Thiago Miranda, de Freitas, Francisco Cleber Silva, Ferreira, Antônio Klingem Leite, de Freitas, Mário Rogério Lima, Mota, James Almada, da Silva, Marco Antonio, de Freitas Clementino, Alexandre, Havt   +8 more
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Sulfation of 6-Gingerol by the Human Cytosolic Sulfotransferases: A Systematic Analysis

Planta Medica, 2015
Previous studies have demonstrated the presence of the sulfated form of 6-gingerol, a major pharmacologically active component of ginger, in plasma samples of normal human subjects who were administered 6-gingerol. The current study was designed to systematically identify the major human cytosolic sulfotransferase enzyme(s) capable of mediating the ...
Lijun, Luo, Xue, Mei, Yuecheng, Xi, Chunyang, Zhou, Ying, Hui, Katsuhisa, Kurogi, Yoichi, Sakakibara, Masahito, Suiko, Ming-Cheh, Liu   +8 more
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Genotoxic effect of 6-gingerol on human hepatoma G2 cells

Chemico-Biological Interactions, 2010
6-gingerol, a major component of ginger, has antioxidant, anti-apoptotic, and anti-inflammatory activities. However, some dietary phytochemicals possess pro-oxidant effects as well, and the risk of adverse effects is increased by raising the use of doses.
Guang, Yang, Laifu, Zhong, Liping, Jiang, Chengyan, Geng, Jun, Cao, Xiance, Sun, Yufang, Ma   +6 more
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Elucidating the Role of Protandim and 6‐Gingerol in Protection Against Osteoarthritis

Journal of Cellular Biochemistry, 2017
ABSTRACTProtandim and 6‐gingerol, two potent nutraceuticals, have been shown to decrease free radicals production through enhancing endogenous antioxidant enzymes. In this study, we evaluated the effects of these products on the expression of different factors involved in osteoarthritis (OA) process.
Abusarah, Jamilah, Benabdoune, Houda, Shi, Qin, Lussier, Bertrand, Martel-Pelletier, Johanne, Malo, Michel, Fernandes, Julio C., de Souza, Fátima Pereira, Fahmi, Hassan, Benderdour, Mohamed   +9 more
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Mechanism of Inhibition of Peroxynitrite-Induced Oxidation and Nitration by [6]-Gingerol

Planta Medica, 2005
[6]-Gingerol potently inhibits peroxynitrite-induced oxidation and nitration reactions, but its mechanism of action is unclear. In order to discover the mechanism of inhibition, [6]-gingerol was reacted with peroxynitrite and the reaction mixture was analyzed using HPLC.
Katsunari, Ippoushi, Hidekazu, Ito, Hideki, Horie, Keiko, Azuma   +3 more
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Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol

Food and Chemical Toxicology, 1994
Antioxidants minimize oxidation of the lipid components in foods. There is an increasing interest in the use of natural and/or synthetic antioxidants in food preservation, but it is important to evaluate such compounds fully for both antioxidant and pro-oxidant properties.
R, Aeschbach, J, Löliger, B C, Scott, A, Murcia, J, Butler, B, Halliwell, O I, Aruoma   +6 more
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Biotransformation of 6-gingerol and 6-shogaol by Aspergillus niger

Phytochemistry, 1993
Abstract 6-Gingerol and shogaol, the pungent constituents of Zingiber officinalis were biotransformed by Aspergillus niger. 6-Gingerol was converted to the corresponding primary alcohol as major product although a keto group is present in the molecule whereas the double bond and keto group of 6-shogaol were reduced and the terminal methyl group was ...
Hironobu Takahashi, Toshihiro Hashimoto, Yoshiaki Noma, Yoshinori Asakawa   +3 more
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