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Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats. [PDF]

Front Pharmacol
Songvut P, Nakareangrit W, Cholpraipimolrat W, Kwangjai J, Worasuttayangkurn L, Watcharasit P, Satayavivad J.   +6 more
europepmc   +1 more source

Regulation of Neuropeptide Y Receptor Gene Expression and Hormone Level in Obese Male Rats Receiving 6-Gingerol and L-Arginine Supplementation. [PDF]

Arch Razi Inst
Karbasian M, Panahi N, Badalzadeh R, Shirazi-Beheshtiha SH, Shahbazzade D.   +4 more
europepmc   +1 more source

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Analgesic and anti-inflammatory activities of [6]-gingerol

Journal of Ethnopharmacology, 2005
In the present study, the analgesic and anti-inflammatory effects of [6]-gingerol, which is the pungent constituent of ginger, were performed. Intraperitoneal administration of [6]-gingerol (25 mg/kg-50 mg/kg) produced an inhibition of acetic acid-induced writhing response and formalin-induced licking time in the late phase.
Hao Yuan Cheng, Wen-Huang Peng, Jung-Chun Liao   +2 more
exaly   +3 more sources

Metabolism of [6]-gingerol in rats

Life Sciences, 2002
The metabolic fate of [6]-gingerol, one of the active constituents of Zingiber officinale Roscoe, was investigated using rats. The bile of rats orally administered [6]-gingerol was shown to contain a major metabolite (1) by HPLC analysis. Although the metabolites derived from [6]-gingerol were not detected in the urine, the ethyl acetate extract of the
Takahiro, Nakazawa, Keisuke, Ohsawa
exaly   +3 more sources

Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats

Biopharmaceutics and Drug Disposition, 2008
Abstract[6]‐Gingerol is one of the pungent components in ginger which has been found to possess various pharmacological effects. However, there is insufficient information on the properties of [6]‐gingerol based on controlled pharmacokinetic studies.
Sui-Qing Mi, Ning-Sheng Wang
exaly   +3 more sources

Effects of standardized [6]-gingerol extracts and [6]-gingerol on isolated ileum and lower esophageal sphincter contractions in mice

Food Chemistry, 2022
Standardized [6]-gingerol extracts were prepared by microwave-assisted extraction using 20% v/v glycerin in ethanol and 20% v/v eutectic mixture of sucrose and citric acid in ethanol as alternative green solvents. The extracts obtained from 20% v/v glycerin in ethanol (GEE) and 20% v/v eutectic mixture of sucrose and citric acid in ethanol (EMSCEE ...
Nantaporn, Promdam, Pissared, Khuituan, Pharkphoom, Panichayupakaranant   +2 more
openaire   +2 more sources

Microsomal Hydroxylation and Glucuronidation of [6]-Gingerol

Journal of Agricultural and Food Chemistry, 2006
[6]-Gingerol is the major pungent principle of ginger and frequently is ingested with various condiments and nutritional supplements. We report here that incubation of [6]-gingerol with NADPH-fortified rat hepatic microsomes gave rise to eight metabolites, which were tentatively identified by GC-MS analysis as two products of aromatic hydroxylation as ...
Pfeiffer, E., Heuschmid, F. F., Kranz, S., Metzler, M.   +3 more
openaire   +2 more sources

The active part of the [6]-gingerol molecule in mutagenesis

Mutation Research Letters, 1983
A study was performed to discover the active part in mutagenesis of [6]-gingerol, a mutagen contained in ginger Zingiber officinale (Nakamura and Yamamoto, 1982). [6]-Shogaol was isolated from the ginger by column chromatography on silica gel. [6]-Shogaol was much less mutagenic (1 X 10(3) revertants/10(8) viable cells/700 microM) than [6]-gingerol (1 ...
H, Nakamura, T, Yamamoto
openaire   +2 more sources