Results 81 to 90 of about 1,071 (121)

[68Ga]Ga-FAPI-46 PET/CT for penile cancer – a feasibility study

European Journal of Nuclear Medicine and Molecular Imaging
Penile cancer is a rare entity and has a good prognosis in localized stage. Delayed surgical treatment of lymphatic disease is associated with poor overall survival but conventional imaging cannot detect occult lymph node metastasis sufficiently. Imaging cancer related fibroblasts has shown promising results as non-invasive staging tool in various ...
Lennert Eismann, Stephan T. Ledderose, Benazir Enzinger, Elena Berg, Thilo Westhofen, Severin Rodler, Gerald B. Schulz, Johannes Toms, Adrien Holzgreve, Franz J. Gildehaus, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Christian G. Stief, Peter Bartenstein, Boris Schlenker, Lena M. Unterrainer   +16 more
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Characterizing Normal Variant [⁶⁸Ga]Ga-FAPI-46 Uptake in the Epididymis

Journal of Nuclear Medicine, 2023
The biodistribution of fibroblast activation protein inhibitor (FAPI) PET tracers includes the kidneys, bladder, uterus, breast, muscles, and bone marrow. We describe its occasional uptake patterns in the epididymis. Methods: Epididymal [68Ga]Ga-FAPI-46 uptake was retrospectively analyzed in 55 PET/CT studies of 55 men. Uptake intensity (SUV), pattern (
Peter George, Maliha, Masatoshi, Hotta, Johannes, Czernin, Jeremie, Calais   +3 more
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Secondary Pulmonary Hypertrophic Osteoarthropathy Detected on [68Ga]Ga-FAPI-46 PET/CT [PDF]

Clinical Nuclear Medicine
A 55-year-old man presented with arthralgia, digital clubbing, and pitting edema. A suspicious pulmonary mass showed high tracer uptake on both [ 18 F]FDG and [ 68 Ga]Ga-FAPI-46 PET/CT. Remarkably, FAPI PET revealed a diffuse periosteal tracer uptake of
Anne-Leen Deleu, Thierry Berghmans, Patrick Flamen, Mariana Brandão   +3 more
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use. [PDF]

Journal of visualized experiments : JoVE
[68Ga]Ga-FAPI-46 is a promising new tracer for the imaging of fibroblast activation protein (FAP) by positron emission tomography (PET). Labeled FAP inhibitors (FAPIs) have demonstrated uptake in various types of cancers, including breast, lung, prostate, pancreatic and colorectal cancer.
Morandeau, Laurence, Ioppolo, Joseph A., Alvarez de Eulate, Eva, Mohamed, Shifaza, Cullen, Danica, Asad, Ali H., Francis, Roslyn J., Atkinson, Janette   +7 more
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Preliminary in-vivo evaluation of [68Ga]Ga-FAPI-46 in a fibroblast activation protein–negative breast cancer model

Nuclear Medicine Communications
Objectives Fibroblast activation protein (FAP), which is abundantly expressed in cancer-associated fibroblasts, is an attractive target for tumour imaging and therapy. [ 68 Ga]Ga-FAPI-46, a gallium-68-labelled FAP inhibitor, has demonstrated ...
Hishar Hassan, Nur Nadhira Jafperi, Wan Hamirul Bahrin Wan Kamal, Saifullizan Mohamad, Anee Suryani Sued, Siti Aminah Muhamad, Mohd Faiz Mustaffa, Nazreen Waeleh, Hairil Rashmizal Abdul Razak, Muhamad Faiz Othman   +9 more
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Optimization and scale-up of [68Ga]Ga-FAPI-46 production on a Modular-Lab PharmTracer platform for clinical application

Nuclear Medicine and Biology
Due to the increasing application of the fibroblast activation protein (FAP) targeting radiotracer [68Ga]Ga-FAPI-46 in cancer diagnostics by PET/CT, there is a need for a convenient way for routine production of high activities of this tracer. The aim of the current work is the optimization and scale-up of an automated method for [68Ga]Ga-FAPI-46 ...
Brusa I, Cabitza VS, Emiliani S, Malizia C, Fortunati E, Zanoni L, Cuzzani G, Farolfi A, Castellucci P, Nanni C, Fanti S, Lodi F.   +11 more
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Controversies of [68Ga]Ga-FAPI-46 and 2-[18F]FDG findings in metastatic melanoma

European Journal of Nuclear Medicine and Molecular Imaging, 2023
Fuad Novruzov, Elnur Mehdi, Nuriyya Orucova, Gunay Aliyeva, Frank Valla, Hidayat Mammadzada, Davut Shahin, Jamil Aliyev   +7 more
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Thyroiditis Induced by Immune Checkpoint Inhibitors Exhibits High [68Ga]Ga-FAPI-46 and [18F]FDG Uptake on PET/CT

Clinical Nuclear Medicine
A 69-year-old man diagnosed with sarcomatoid pleural mesothelioma received 3 cycles of nivolumab with 2 cycles of ipilimumab. Treatment was terminated after the patient developed colitis—an immune-related adverse event (irAE). High-dose prednisolone was initiated.
Anne H. Thostrup, Morten Bentestuen, Thor L. Rasmussen, Weronika M. Szejniuk, Helle D. Zacho   +4 more
openaire   +1 more source

First clinical results of [68Ga]Ga-FAPI-46 PET/CT in squamous penile cancer

Nuklearmedizin - NuclearMedicine, 2023
L. Eismann, J. Toms, A. Holzgreve, E. Berg, M. Scheifele, S. Rodler, F. J. Gildehaus, M. Brendel, N. L. Albert, C. C. Cyran, P. Kazmierczak, W. G. Kunz, S. T. Ledderose, C. G. Stief, P. Bartenstein, M. Unterrainer, B. Schlenker, L. M. Unterrainer   +17 more
openaire   +1 more source

Evaluation of locoregional invasiveness of early lung adenocarcinoma manifesting as ground-glass nodules via [68Ga]Ga-FAPI-46 PET/CT imaging

European Journal of Nuclear Medicine and Molecular Imaging
Accurate differentiation of the histologic invasiveness of early-stage lung adenocarcinoma is crucial for determining surgical strategies. This study aimed to investigate the potential of [68Ga]Ga-FAPI-46 PET/CT in assessing the invasiveness of early lung adenocarcinoma presenting as ground-glass nodules (GGNs) and identifying imaging features with ...
Dan Ruan, Sien Shi, Weixi Guo, Yizhen Pang, Lingyu Yu, Jiayu Cai, Zhenyu Wu, Hua Wu, Long Sun, Liang Zhao, Haojun Chen   +10 more
openaire   +2 more sources