Results 21 to 30 of about 1,421 (219)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Assessing users' subjective satisfaction with the Information System for Youth Services (ISYS) [PDF]

, 1998
In this investigation, the Questionnaire for User Interaction Satisfaction (QUIS 5.5), a tool for assessing users' subjective satisfaction with specific aspects of the human/computer interface was used to assess the strengths and weaknesses of the Info ...
Norman, Kent L., Slaughter, Laura, Shneiderman, Ben   +2 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A documentation paradigm for an integrated software maintenance support environment [PDF]

, 1992
Recent advances in computer hardware have not been matched by comparable advances in computer software, inhibiting the production of reliable software at greater levels of productivity.
Bittlestone, David
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Visual Depictions of Search Results: using glyphs and coordinated multiple-views [PDF]

, 2004
Jonathan Roberts, Nadia Boukhelifa, Peter Rodgers have developed a system that can visualize search-result data using glyphs and coordinated multiple-views.
Boukhelifa, Nadia, Rodgers, Peter, Roberts, Jonathan, Roberts, Jonathan C.   +3 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Aprender, atividade inteligente :: e se esta inteligência for parcialmente artificial? / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro ...
Almeida, Maria Aparecida Fernandes
core  

Universities and article copyright

, 2000
In all the debates about copyright and intellectual property in recent years, the battle lines have tended to be drawn between librarians and publishers. This neglected what in some ways is the most important player of all, the employer.
Sheen, M.R., Weedon, Ralph, Law, Derek, Weedon, R. L., Law, D. G.   +4 more
core   +1 more source

Bridging the gap between digital libraries and e-learning [PDF]

, 2015
Digital Libraries (DL) are offering access to a vast amount of digital content, relevant to practically all domains of human knowledge, which makes it suitable to enhance teaching and learning.
Dobreva, Milena, Agre, Gennady, Angelova, Galia   +2 more
core   +1 more source