Results 121 to 130 of about 1,875,901 (219)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pyroelectric Properties of A-Site Ordered [K_0.5Na_0.5]NbO₃ Perovskite Studied with Hybrid Density Functional Method

Kim Eklund, Antti J. Karttunen
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A connectivity threshold between grass patches amplifies coastal dune formation. [PDF]

Nat Commun
Berghuis PMJ, Reijers VC, van de Koppel J, Mayor AG, Scheifes DJP, Rietkerk M, van der Heide T.   +6 more
europepmc   +1 more source

A generalized version of Holmstedt's formula for the K-functional [PDF]

Irshaad Ahmed, Alberto Fıorenza, Амиран Гогатишвили   +2 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The k nearest neighbors local linear estimator of semi functional partial linear model with missing response at random

Amina Naceri, Tawfik Benchikh, Ibrahim M. Almanjahie, Omar Fetitah, Mohammed Kadi Attouch, Fatimah Alshahrani, Ecole Supérieure en Informatique, Sidi Bel Abbes, 22000, Algeria; Email: am.naceri@esi-sba.dz, o.fetitah@esi-sba.dz   +6 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Functional brain connectivity in patients with <i>de novo</i> Parkinson's disease. [PDF]

Neuroimage Rep
Picchi E, Minosse S, Pucci N, Conti M, Mascioli D, Stefani A, Garaci F, Ferrazzoli V, Da Ros V, Schirinzi T, Di Giuliano F.   +10 more
europepmc   +1 more source

One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization [PDF]

, 2015
Kyohei Ozaki, Katsuaki Kawasumi, Mari Shibata, Hideto Ito, Kenichiro Itami   +4 more
openalex   +1 more source