Results 101 to 110 of about 23,383,453 (236)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Special edition of ABC News 20/20 on aftermath of Super storm Sandy
, 2012 Diane Sawyer and Chris Cuomo of ABC News co-anchored Special Edition of 20/20: The Perfect Storm _ __ _ ___ _ __ _ ___ taking viewers inside the harrowing stories of determination by those caught in the storm _ __ _ ___ _ __ _ ____ _ ...
ABC News 20/20
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The Critical Role of G-20 in Dealing with the 2008 Global Financial Crisis [PDF]
, 2017 Strategi G-20 dalam mengatasi krisis keuangan telah dinyatakan pada kesepakatan KTT G-20 2008-2009 dengan adanya tiga pertemuan selama periode tersebut berlangsung (Washington, London dan Pittsburgh). Bersama dengan beberapa lembaga termasuk IMF, WB, FSB,
Priangani, A. (Ade) +2 more
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2011 ORGANISASI INTERNASIONAL LANJUTAN G-20 menjadi salah satu kajian dalam organisasi internasional lanjutan, karena merupakan sebuah komunitas ekonomi baru dunia, yang terdiri dari negara-negara industri maju dan negara berkembang yang dianggap memiliki ...
Triwahyuni, Dewi
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Warren G. Harding letter to Myron T. Herrick, December 20, 1919
, 1919 In this letter dated December 20, 1919, Senator Warren G. Harding writes to former Ohio Governor Myron T. Herrick in response to his letter of December 18.
Harding, Warren G. (Warren Gamaliel), 1865-1923
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source