Results 61 to 70 of about 7,591,664 (247)

Significance of multi-level fusion in multi-component fault diagnosis under speed varying condition in rotational machinery [PDF]

FME Transactions
Most well-known challenging effects of identifying multiple defects in a rotational machine when speed is varied, are illustriously inspected by many researchers.
Saimurugan M., Sowmya S., Edinbarough Immanuel   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Collaborative Optimization Method for Train Wheel-rail Adhesion Control and Safety Resilience in Four-network Integration Scenario

Chengshi guidao jiaotong yanjiu
[Objective] With With the increasing demands for multi-system coordinated rail transit development in China under the "four-network integration" （mainline railways， intercity railways， suburban railways， and urban rail transit） framework， train ...
LI Liran, YIN Zhenhuan, ZHAO Leiting, LIU Kan, CHEN Yujie   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical Investigation of Aerodynamic Interactions in a Twin-Propeller Compound Helicopter

Aerospace
High-speed compound helicopters surpass the forward-speed limits of conventional helicopters and expand the flight envelope, yet close multi-component integration induces complex aerodynamic interference, whose underlying mechanisms and evolution with ...
Yutong Wang, Jiahao Song, Haomiao Xia, Qinchuan Hou   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi-objective Economic Scheduling of Distribution Networks with FISCO BCOS and Topology Optimization Consistency Algorithm [PDF]

Jisuanji gongcheng
The high penetration of distributed energy, addition of many energy storage units, and flexible loads have hindered the optimization and scheduling of active distribution networks.
WANG Guilan, ZHANG Cheng, ZHOU Guoliang
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Revolutionizing multi‐omics analysis with artificial intelligence and data processing

Quantitative Biology
Our understanding of intricate biological systems has been completely transformed by the development of multi‐omics approaches, which entail the simultaneous study of several different molecular data types.
Ali Yetgin
doaj   +1 more source