Results 51 to 60 of about 7,591,664 (247)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Two-photon 3D imaging of optically stimulated neural activity at 100 Hz

Light: Science & Applications
Understanding how neurons integrate synaptic inputs requires imaging techniques capable of capturing rapid, three-dimensional dendritic events. These processes occur on millisecond timescales and submicron spatial scales, exceeding the speed of ...
Dongli Xu, Fuu-Jiun Hwang, Jun B. Ding, Leilei Peng   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Optimization Scheduling of Multi-Regional Systems Considering Secondary Frequency Drop

Energies
After primary frequency regulation in large-scale wind farms is completed, the power dip phenomenon occurs during the rotor speed recovery phase. This phenomenon may induce a secondary frequency drop in power systems, which poses challenges to system ...
Xiaodong Yang, Xiaotong Hua, Lun Cheng, Tao Wang, Yujing Su   +4 more
doaj   +1 more source

Suppression of period doubling chetter in high-speed milling by spindle speed variation [PDF]

, 2011
Spindle speed variation is a well known technique to suppress regenerative machine tool vibra- tions, but it is usually considered to be effective only for low spindle speeds.
Arnaud, Lionel, Tamás Insperger, Lionel Arnaud, Grégoire Peigné, Insperger, Tamás, Sébastien Seguy, Peigné, Grégoire, Seguy, Sébastien, Dessein, Gilles, Gilles Dessein   +9 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Multi-response optimization of carbon fiber reinforced polymer (CFRP) drilling using back propagation neural network-particle swarm optimization (BPNN-PSO)

Engineering Science and Technology, an International Journal, 2020
An integrated approach has been applied to predict and optimize multi-performance-characteristics, being optimum thrust force (FTh), torque (M), hole entry delamination (FDen) and hole exit delamination (FDex), in the drilling process of carbon fiber ...
Bobby Oedy Pramoedyo Soepangkat, Rachmadi Norcahyo, M. Khoirul Effendi, Bambang Pramujati   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Torque Impulse Balance Control for Multi-Tooth Fault Tolerant Switched-Flux Machines under Open-Circuit Fault

Energies, 2018
The multi-tooth fault tolerant switched-flux machines (MTFTSFM) providing both excellent fault tolerant capability and relatively high torque density are good choices for high reliability applications.
Yu Wang, Wenjuan Hao
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source