Results 41 to 50 of about 7,591,664 (247)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

European Green Deal: Slowing Down Multi-Speed Integration with Innovation [PDF]

, 2021
With the creation of the Green Deal, the European Union aims to achieve the goal of climate-neutrality by 2050. Multi-speed European integration is very likely to take place during the procedure of transition, if the proper precautions are not taken ...
Axarli, Dimitra
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Centimeter-Scale Reconfiguration Piezo Robots with Built-in-Ceramic Actuation Unit

Engineering
Reconfigurable robots have been widely used in the fields of environmental exploration and multi-task applications, benefitting from their high adaptability and multi-functionality.
Yu Gao, Jing Li, Shijing Zhang, Jie Deng, Weishan Chen, Yingxiang Liu   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Advancing multi-hazard resilience and urban integration: A quantitative framework for high-speed rail stations

Environmental and Sustainability Indicators
With rapid urbanization and increasing extreme weather events, high-speed rail (HSR) stations must not only function as efficient transport nodes but also exhibit robust multi-disaster resilience and seamless integration with their urban surroundings ...
Siyan Wang, Beilei Hua, Peixian Li, Alessandra Travasso, Xing Shi   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Integration of an application accelerator for high speed inspection

, 2022
S.222-227Industrial applications of vision systems for inspection very often require high speed performance. Using an application accelerator in combination with a PC-based vision system, a speed-up factor of about 10-15 can be realized. Algorithms using
Hager, K., Kille, K., Ahlers, R.-J.
core   +1 more source

An Innovative Variable Magnetic Gear Synchronous Motor Topology for Electric Vehicles

ITEGAM-JETIA
The Electric vehicle (EV) performance is critically dependent on the balance between speed and torque, which is managed through the ongoing development of motor technologies and control strategies.
kamel Salim Belkhir, Houcem Achouri, Kawther Fatmi   +2 more
doaj   +1 more source