Results 121 to 130 of about 3,298,579 (267)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Yleisten kirjastojen asiakkaat elektronisten aineistojen käyttäjinä

Informaatiotutkimus, 2010
Katsaus perustuu Kati Mattssonin informaatiotutkimuksen pro gradu -tutkielmaan; Elektronisten aineistojen käyttö yleisissä kirjastoissa. Mattssonin tutkimus on osa FinELibin ja Tampereen yliopiston Informaatiotutkimuksen laitoksen yhteistyötä, jonka ...
Kati Mattsson, Elina Late
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential safety profiles of durvalumab monotherapy and durvalumab in combination with tremelimumab in adult patients with advanced cancers

Journal for ImmunoTherapy of Cancer
Background Durvalumab (D; anti-programmed cell death ligand 1 (PD-L1)) monotherapy or in combination with tremelimumab (T; anti-cytotoxic T lymphocyte antigen-4 (CTLA-4)) have demonstrated efficacy in advanced cancers.
Mayur Patel, John Kurland, Claire Morgan, Cathy O’Brien, Pamela Concepcion, Gary J Doherty, Stephan Hois, Alejandra Negro, Dejan Pavlovic, Karen A Robbins   +9 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Late Pliocene lakes and soils: a global data set for the analysis of climate feedbacks in a warmer world

, 2014
The global distribution of late Pliocene soils and lakes has been reconstructed using a synthesis of geological data. These reconstructions are then used as boundary conditions for the Hadley Centre General Circulation Model (HadCM3) and the BIOME4 ...
H. J. Dowsett, Haywood, Alan, Tindall, J, Pickering, SJ, Salzmann, U, Pound, Matthew, Haywood, AM, Dowsett, Harry, U. Salzmann, Pound, MJ, Salzmann, Ulrich, A. M. Haywood, Tindall, Julia, Dowsett, HJ, M. J. Pound, Pickering, Steven, J. Tindall, S. J. Pickering   +17 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Late Cretaceous Vertebrates from the Western Interior

, 2006
Late Cretaceous; Cretaceous; vertebrates; Western ...
Spencer G. Lucas and Robert M. Sullivan, eds.
core  

The chronology of the Aegean late bronze age with special reference to the "Minoan” eruption of Thera [PDF]

, 2002
The chronology of the Aegean Late Bronze Age is a vigorously contested area of archaeological study, with "high" and "low" schemes emerging over the last three decades.
Dunn, Stuart E
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source