Results 131 to 140 of about 2,173,288 (218)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dementia risk by metabolic health and obesity in two prospective cohorts. [PDF]

BMC Med
Nakash M, Ojalehto Lindfors E, Zhan Y, Dahl Aslan AK, Reynolds CA, Ler P, Karlsson IK.   +6 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

WCN24-1980 Efficacy and safety of zibotentan in combination with dapagliflozin in patients with CKD according to baseline diabetes status and kidney function

Kidney International Reports
Hiddo Lambers Heerspink, Arihiro Kiyosue, David Wheeler, Min Lin, Emma Wijkmark, Glenn Carlson, Anne-Kristina Mercier, Magnus Astrand, Sebastian Ueckert, Peter J. Greasley, Phil Ambery   +10 more
doaj   +1 more source

Early timepoint ^99mTc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis. [PDF]

EJNMMI Res
Settelmeier S, Kessler L, Hammersen N, Papathanasiou M, Rischpler C, Carpinteiro A, Oubari S, Michel L, Vogel J, Wollenweber T, Ning J, Hacker M, Spielvogel CP, Varasteh Z, Fendler WP, Barbato F, Costa PF, Leyser S, Rassaf T, Herrmann K, Telli T, Kersting D.   +21 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hippocampal GFAP in aging: Associations with AD and LATE-NC pathologies and cognitive decline in older adults. [PDF]

Alzheimers Dement
Agrawal S, Yu L, Leurgans SE, Li J, Kapasi A, Agarwal P, Dage JL, Barnes LL, Bennett DA, Boyle P, Schneider JA.   +10 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Robotic versus laparoscopic pancreatoduodenectomy across the learning curve: a systematic review and meta-analysis. [PDF]

Langenbecks Arch Surg
Abdelsamad A, Mohamed K, Badie Y, Hussein Z, Mohsen M, Selim O, Mohamed O, Mohammed MK, Wesh ZM, Nickel F, Vaghiri S, Gebauer F.   +11 more
europepmc   +1 more source