Mitophagy in Hypertensive Cardiac Hypertrophy: Mechanisms and Therapeutic Implications. [PDF]
J Clin Hypertens (Greenwich)ABSTRACT Hypertensive cardiac hypertrophy (HCH) is a compensatory response to chronic pressure overload, ultimately progressing to heart failure if left unmanaged. Emerging evidence highlights the critical role of mitochondrial dysfunction in HCH pathogenesis, with impaired mitophagy—a selective autophagic process that removes damaged mitochondria ...
Li S, Li X.
europepmc +2 more sources
CHB-Induced Immune Zonation Chaos Elicited LXRα-mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation. [PDF]
Adv Sci (Weinh)By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Shi J +18 more
europepmc +2 more sources
Legacy pollutants are declining in Great Skuas (Stercorarius skua) but remain higher in Faroe Islands than in Scotland [PDF]
, 2016 To monitor environmental pollutants in Faroese biota, samples from a top predator were analysed and put into a spatial and temporal context. Analysis of 20 Great Skua eggs sampled in 2012 from the Faroe Islands showed >70 % lower concentrations of ...
Alonso, Sarah +5 more
core +2 more sources
La gaviota dominicana como bioindicador de los productos químicos ambientales en la región de Magallanes. Una comparación con otras localidades costeras en Chile [PDF]
, 1999 During the breeding seasons 1994/5 and 1995/6 we collected Kelp Gull (Larus dominicanus) eggs from five locations in central to south Chile to study the contamination with mercury and organochlorine compounds. The sites were Algarrobo, Concepción,
Becker, Peter H., Muñoz, Jacqueline
core +4 more sources
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
, 2012 Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
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A biomonitoring study on blood levels of beta-hexachlorocyclohexane among people living close to an industrial area [PDF]
, 2013 BACKGROUND: A chemical plant manufacturing pesticides has been operating since the 1950’s in the Sacco River Valley (Central Italy). In 2005, high beta-hexachlorocyclohexane (Beta-HCH) concentrations were found in milk of cows raised and fed near the ...
Anna Maria Ingelido +9 more
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Internal exposure to perfluoroalkyl substances (PFASs) and biological markers in 101 healthy 1-year-old children: associations between levels of perfluorooctanoic acid (PFOA) and vaccine response [PDF]
, 2020 Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA)
Abraham, Klaus +8 more
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Effects of biometrics, location and persistent organic pollutants on blood clinical-chemical parameters in polar bears (Ursus maritimus) from Svalbard, Norway [PDF]
, 2018 Embargo until 31 May 2020.In the present study, blood clinical-chemical parameters (BCCPs) were analysed in 20 female and 18 male Svalbard polar bears (Ursus maritimus) captured in spring 2007.
Aars, Jon +6 more
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Untersuchungen zur estrogenen Potenz endokrin wirksamer Umweltchemikalien an Primärkulturen humaner Endometriumzellen [PDF]
, 2006 Endokrin wirksame Umweltchemikalien mit estrogenem Potential stellen eine mögliche Gefahr für die Reproduktionsfähigkeit des Menschen dar. Sie sind selbst bei Nichtexponierten in verschiedenen Geweben nachweisbar, so auch im Endometrium, in welchem vor ...
Hippe, Sabine
core +1 more source
The influence of organochlorine compound exposure on the physiological development of children [PDF]
The present study summarizes the advances on the knowledge of the health disturbances associated to fetal exposure to organochlorine compounds in a cohort of children from Menorca.
Grimalt, Joan O. +2 more
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