18F- FDG PET/CT IN MELANOMA OF PROBABLE ANORECTAL ORIGIN: CASE REPORT
Hematology, Transfusion and Cell TherapyIntroduction/Justification: Anorectal melanoma is a rare tumor that develops in melanin producing pigment cells of the anus and rectum. As a rare entity there is not much literature regarding the management of this pathology.
Felipe Piccarone Gonçalves Ribeiro +7 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A pilot study of the effects of hormone therapy on normal breast tissue of postmenopausal women [PDF]
, 2006 PURPOSE: to analyze breast tissue of postmenopausal women before and after six months of continuous combined estrogen-progestin replacement therapy (0.625 mg conjugated equine estrogens associated with 2.5 mg medroxyprogesterone acetate).
Baracat, Edmund Chada +6 more
core +3 more sources
Resiliência e Fragilidade dos Sistemas de Trabalho e Sustentabilidade: estudos de casos de sistemas sócio-técnicos complexos no Brasil na área nuclear, aviação e emergência [PDF]
, 2009 David D. Woods +4 more
openalex +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Regional Genetic Structure in the Aquatic Macrophyte Ruppia cirrhosa Suggests Dispersal by Waterbirds [PDF]
, 2017 The evolutionary history of the genus Ruppia has been shaped by hybridization, polyploidisation and vicariance that have resulted in a problematic taxonomy. Recent studies provided insight into species circumscription, organelle takeover by hybridization,
A Marchioni-Ortu +71 more
core +2 more sources
Análise do processo de avaliação de um programa de cooperação técnica internacional na área nuclear [PDF]
, 2021 GABRIELA BORSATTO +2 more
openalex +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Local pottery from the ravine of Las Pitas river (Catamarca, Argentina).Contributions to the study of people, knowledge and object circulation in Antofagasta de la Sierra during the Late Period [PDF]
, 2017 El trabajo aborda el problema de la producción cerámica durante el período Tardío en la quebrada del río Las Pitas (microrregión de Antofagasta de la Sierra). Desde esta perspectiva, se integra información estilística, petrográfica y química.
Invernizzi, Rodrigo +2 more
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