Results 91 to 100 of about 930,467 (263)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Simulation of the Lower Head Boiling Water Reactor Vessel in a Severe Accident

Science and Technology of Nuclear Installations, 2012
The objective of this paper is the simulation and analysis of the BoilingWater Reactor (BWR) lower head during a severe accident. The COUPLE computer code was used in this work to model the heatup of the reactor core material that slumps in the lower ...
Alejandro Nuñez-Carrera, Raúl Camargo-Camargo, Gilberto Espinosa-Paredes, Adrián López-García   +3 more
doaj   +1 more source

Distributional extensions of Carollia castanea and Micronycteris minuta from Guatemala, Central America [PDF]

, 2017
Field expeditions in 2011 that inventoried the terrestrial vertebrate fauna of two wildlife protected areas in the tropical Caribbean of Guatemala have produced the first confirmed records of two bats for the country: the white-bellied big-eared bat ...
Barahona, R, López, JE, Nicolle, JA, Ordóñez-Sayle, EJ, Patton, JL, Pérez-Consuegra, SG, Vázquez-Domínguez, E   +6 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Indicadores de sustentabilidade para institutos de pesquisa e inovação da área nuclear

Brazilian Journal of Radiation Sciences, 2016
Indicadores são ferramentas relevantes no processo de mensuração da sustentabilidade.  No presente estudo é discutida a relevância de indicadores de sustentabilidade apropriados para institutos de pesquisa e inovação no Brasil.
Simone Fonseca Alves, Alberto Avellar Barreto, Paulo César Horta Rodrigues, Vanusa Maria Delage Feliciano   +3 more
doaj   +1 more source

External Dose to Recovery Teams Following a Wide-area Nuclear or Radiological Release Event. [PDF]

Health Phys, 2021
Kaminski MD, Sanders K, Hepler K, Magnuson M, Slagley J.   +4 more
europepmc   +1 more source

Releasing systems for aerospace industry based upon shape memory alloys: Characterization of materials for actuators [PDF]

, 2018
Releasing and deployment maneuvers carried out during space satellites launching are usually performed by utilizing pyrotechnics loads. However, it is considered convenient to replace this technique by others not requiring explosives (Non Explosive ...
Glücksberg, Andrés, Soul, Hugo Ramon, Yawny, Alejandro Andres   +2 more
core   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

18F- FDG PET/CT IN MELANOMA OF PROBABLE ANORECTAL ORIGIN: CASE REPORT

Hematology, Transfusion and Cell Therapy
Introduction/Justification: Anorectal melanoma is a rare tumor that develops in melanin producing pigment cells of the anus and rectum. As a rare entity there is not much literature regarding the management of this pathology.
Felipe Piccarone Gonçalves Ribeiro, Thiago Ferreira de Souza, Dihego Ferreira dos Santos, Allan de Oliveira Santos, Mariana da Cunha Lopes de Lima, Elba Cristina Sá de Camargo Etchebehere, Celso Darío Ramos, Bárbara Juarez Amorim   +7 more
doaj   +1 more source

Relation between width of zero-bias anomaly and Kondo temperature in transport measurements through correlated quantum dots: Effect of asymmetric coupling to the leads [PDF]

, 2018
The zero-bias anomaly at low temperatures, originated by the Kondo effect when an electric current flows through a system formed by a spin-1/2 quantum dot and two metallic contacts is theoretically investigated.
Aligia, Armando Ángel, Perez Daroca, Diego Raul, Roura Bas, Pablo Gines   +2 more
core   +2 more sources