Results 21 to 30 of about 699,930 (194)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Utility of the PET/CT in the characterization of the solitary pulmonary nodule

open access: yesSaúde & Tecnologia, 2015
Background – The cancer of lung/trachea and bronchi is the leading cause of death from cancer in the European Union. Dual time in Positron Emission Tomography/Computed Tomography (PET/CT) technique has been referred in some articles as a great value in ...
Ana Graça   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

El área nuclear como indicador diagnóstico en el carcinoma ductal de la mama: un estudio metaanalítico The nuclear area as a diagnostic indicator in the ductal breast carcinoma: a meta-analytical study

open access: yesRevista Cubana de Investigaciones Biomédicas, 2004
Se presentaron los resultados de un metaanálisis dirigido a examinar la eficiencia del área nuclear de las células tumorales, como un indicador morfométrico capaz de detectar la presencia de malignidad en la neoplasia de la mama.
Pedro A Díaz Rojas, Julio Sánchez Meca
doaj  

Wetting of Nematic Liquid Crystals on Crenellated Substrates: A Frank–Oseen Approach

open access: yesCrystals, 2019
We revisit the wetting of nematic liquid crystals in contact with crenellated substrates, studied previously using the Landau−de Gennes formalism.
Óscar A. Rojas-Gómez   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Severe Accident Simulation of the Laguna Verde Nuclear Power Plant

open access: yesScience and Technology of Nuclear Installations, 2012
The loss-of-coolant accident (LOCA) simulation in the boiling water reactor (BWR) of Laguna Verde Nuclear Power Plant (LVNPP) at 105% of rated power is analyzed in this work. The LVNPP model was developed using RELAP/SCDAPSIM code.
Gilberto Espinosa-Paredes   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Guía de buenas prácticas clínicas para la atención al niño con neumonía adquirida en la comunidad

open access: yesMedisur, 2019
La neumonía adquirida en la comunidad es frecuente en la edad pediátrica. El objetivo de este trabajo es exponer una guía de práctica médica, que sirva para abordar elementos sobre diagnóstico, epidemiología, etiología, factores de riesgos, clasificación
Daylin Madruga Jiménez   +3 more
doaj  

The utility of PET/CT with 18F-FDG in the study of Hodgkin's lymphoma and non-Hodgkin's lymphoma

open access: yesSaúde & Tecnologia, 2015
The lymphomas are tumors established in the lymphatic system. Due to their heterogeneity they can be classified as Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL), presenting each type of lymphoma, different prognosis and chemotherapeutic ...
Marta Milhões   +4 more
doaj   +1 more source

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