Results 91 to 100 of about 745,580 (245)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

open access: yesAdvanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen   +15 more
wiley   +1 more source

Nomenclatural notes on Chalepini and Sceloenopliini (Coleoptera: Chrysomelidae: Cassidinae) [PDF]

open access: yes, 2010
The authorship and type species of the genera Acentroptera and Metazycera are reviewed. The correct author of Acentroptera is Guérin-Méneville, 1844; Acentroptera dejeani Guérin-Méneville, 1844, is here designated as the type species.
Staines, Charles L.
core  

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

open access: yesAdvanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang   +12 more
wiley   +1 more source

La sujétion des médias traditionnels aux dispositifs mobiles de publication : Le cas des applications sur smartphone

open access: yesInterfaces Numériques, 2018
Poussées par l’évolution des usages, les chaînes historiques de télévision ont engagé depuis 2009 la publication de leurs applications sur les smartphones.
Virginie Sonet
doaj   +1 more source

Reseñas [PDF]

open access: yes, 2014
Obra ressenyada: Laurence MOULINIER-BROGI, Guillaume l'Anglais, le frondeur de l'uroscopie médiévale (XIIIe siècle): édition commentée et traduction du De urina non visa.
Cifuentes Comamala, Lluís
core  

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Towards a Model of Designing an Organizational Structure in a Knowledge Based Society [PDF]

open access: yes
The role of the manager in the knowledge society is to lead, in a productive and cost effective manner, a system that is at the crossroads of three worlds: the environment, the human and the organization. To ensure the continuity of the organization, the
Eric Jolivet, Mihai Vărzaru
core  

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

open access: yesAdvanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang   +4 more
wiley   +1 more source

Harragas e nuovi cittadini. Il migrante nella letteratura marocchina di espressione francese tradotta in Italia

open access: yesItalies, 2010
Il fine di questo articolo è analizzare come la rappresentazione letteraria di scrittori maghrebini contribuisce in Italia alla costruzione simbolica dell’immaginario dei migranti.
Paola Checcoli
doaj   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

open access: yesAdvanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li   +13 more
wiley   +1 more source

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