Results 91 to 100 of about 3,093,684 (246)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Laboreal, 2014 This study was requested by a departmental firefighting and rescue school for firefighters in France. Based on ergonomics and professional didactics approaches, the aim is to analyze the activity of driving two emergency vehicles so to improve the ...
Christine Vidal-Gomel +2 more
doaj
L’évaluation de la qualité des systèmes de formation
Mesure et Évaluation en Éducation, 2001 L’évaluation de la qualité des systèmes de formation, qu’ils soient éducatifs ou professionnels, nécessite de prendre en compte des critères d’ordre économique (l’efficacité et l’efficience) et d’ordre social (l’équité), mais aussi d’ordre pédagogique (l’
François-Marie Gerard
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Positive Discrimination Policies and Indigenous-Based ECEC Services in Bogota, Colombia
Social Sciences, 2019 This article aims to present a few tensions and contradictions when implementing children’s rights using the case of three Casas de Pensamiento Indígena (CPI)—indigenous childcare services—in Bogotá.
Carmen María Sanchez Caro
doaj +1 more source
Stratégie d'enseignement portant sur l'utilisation de la fonction "Aide" des logiciels et de ses composantes [PDF]
, 1999 Essai présenté à la Faculté d'éducation en vue de l'obtention du grade de Maître en éducation (M. Éd.)Titre de l'écran-titre (visionné le 6 mars. 2013)Également disponible en version papier.M. Éd.
Boulianne, Jocelyne +1 more
core
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source