Results 101 to 110 of about 3,226,917 (249)

À la rencontre de l’histoire

, 1997
Si l’on dispose de travaux d’historiographie et d’épistémologie, de réflexions sur les finalités de l’histoire enseignée — enjeux de connaissance et de mémoire, formation intellectuelle et identitaire, critique et civique —, rares sont les recherches qui
Lautier, Nicole
core   +1 more source

Quelle convergence entre la géographie et l’histoire dans une perspective d’« éducation à l’environnement pour un développement durable » ? [PDF]

, 2019
Dans l’enseignement secondaire français, l’éducation à l’environnement apparaît comme un objectif transversal aux disciplines scolaires et pose de façon récurrente la question de l’articulation des différentes matières d’enseignement, de leurs méthodes ...
Mainar, Christine Vergnolle
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Généralisabilité et séquences didactiques : illustration et défense d’un modèle à vocation édumétrique

Mesure et Évaluation en Éducation, 2003
La généralisabilité est un modèle statistique particulièrement adéquat quand il s’agit de mettre au point des dispositifs visant à évaluer des apprentissages.
Daniel Bain
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Competências coletivas e formação em condução de veículos de socorro num contexto de especialização de bombeiros sapadores em França

Laboreal, 2014
This study was requested by a departmental firefighting and rescue school for firefighters in France. Based on ergonomics and professional didactics approaches, the aim is to analyze the activity of driving two emergency vehicles so to improve the ...
Christine Vidal-Gomel, Catherine Delgoulet, Céline Geoffroy   +2 more
doaj  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Éducation en Picardie

, 2017
Le carnet « Éducation en Picardie » est créé dans le cadre du projet de recherche « Preuve », qui a débuté en novembre 2015, et est financé par le Conseil régional des Hauts de France ainsi que le FEDER. Celui-ci regroupe plusieurs chercheur(e)s issu(e)s
Equipe de recherche "Preuve"
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Notes on the Phuan Lects Spoken in Xiengkhouang, Thathom, and Borikhane (Laos)

Journal of the Southeast Asian Linguistics Society
This study on Phuan first introduces the areas of Laos investigated in Xiengkhouang, Xaysômboun, and Bolikhamxay provinces. A historical account of Xiengkhouang, regarded as the Phuan homeland, is provided.
Pacquement, Jean
doaj