Results 91 to 100 of about 3,194,804 (248)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Le choix de l’école secondaire de langue française en Ontario par les parents

open access: yesLien Social et Politiques, 2011
L’éducation représente une ressource centrale dans les nouvelles économies du savoir du XXIe siècle et la notion de choix scolaire est examinée ici dans le contexte de recomposition de l’État.
Nathalie Bélanger
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Predicting academic achievement: The role of Motivation and Learning Strategies [PDF]

open access: yes, 2014
The aim of this study consists in testing a predictive model of academic achievement including motivation and learning strategies as predictors. Motivation is defined as the energy and the direction of behaviors; it is categorized in three types of ...
de la Iglesia, Guadalupe   +3 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Généralisabilité et séquences didactiques : illustration et défense d’un modèle à vocation édumétrique

open access: yesMesure et Évaluation en Éducation, 2003
La généralisabilité est un modèle statistique particulièrement adéquat quand il s’agit de mettre au point des dispositifs visant à évaluer des apprentissages.
Daniel Bain
doaj   +1 more source

Participation, citoyenneté et éducation [PDF]

open access: yes, 2013
En los últimos años del siglo XX ha empezado a revitalizarse la ética de las virtudes al hilo de dos teorías ético-políticas que se proponen como alternativa al liberalismo dominante: el comunitarismo y el republicanismo.
Guichot Reina, Virginia
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Competências coletivas e formação em condução de veículos de socorro num contexto de especialização de bombeiros sapadores em França

open access: yesLaboreal, 2014
This study was requested by a departmental firefighting and rescue school for firefighters in France. Based on ergonomics and professional didactics approaches, the aim is to analyze the activity of driving two emergency vehicles so to improve the ...
Christine Vidal-Gomel   +2 more
doaj  

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