Results 81 to 90 of about 3,194,804 (248)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Compétences en lecture à Genève : influence des caractéristiques des élèves et des classes à différents moments de la scolarité obligatoire

Mesure et Évaluation en Éducation, 2010
À Genève, au cours de la scolarité obligatoire, l’institution scolaire met en oeuvre des évaluations externes qui visent, notamment, à dresser un bilan des connaissances et des compétences acquises en vue de décisions de promotion, d’orientation ou de ...
Franck Petrucci
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

L’éducation en vue d’un développement durable: enjeux, objectifs et pistes pratiques interdisciplinaires [PDF]

, 2015
Le présent article propose des pistes de réflexion susceptibles d'aider à penser les programmes scolaires à travers l'idée d'urie éducation en vue d'un développement durable (EDD).
Bourqui, François, Gremaud, Bertrand, Pellaud, Francine, Rolle, Lionel   +3 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Les Organisations de la Société Civile et la Lutte Contre la Pauvreté en Afrique Subsaharienne [PDF]

, 2004
The paper presents the role played by civil society organisations to bring down the ...
Aurélien C. Atidegla, Celestin Hounkpe, Elisabeth Paul, Gregor Stangherlin, Latifou Yessoufou, Magloire Cossou, Marc Labie, Marc Poncelet, Marthe Nyssen, Mathieu Soglonou, Pascal Wele, Simon-Narcisse Tomety   +11 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Research policy and practice - commitment, complexity and uncertainty: a case study of a government research council funded project, engineering the future [PDF]

, 2009
Evidence based policy formation, both at EU and national level, built upon close linkage of research, policy and practice is regarded by many as an optimum solution.
Ekevall, E., Hayward, L., MacBride, G., Spencer, E.   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

L’enseignement-apprentissage de la grammaire : de l’approche communicative à la perspective actionnelle, le cas de la classe de Terminale en Tunisie [PDF]

Synergies France, 2018
S’il est une approche qui a marqué l’enseignement-apprentissage des langues c’est bel et bien l’approche communicative, en vogue dès les années soixante-dix, et dont les soubassements se font ressentir de nos jours.
Mhadeb Boudabous
doaj