Results 101 to 110 of about 3,093,684 (246)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Tiré de: Prospectives, vol. 15, no 2.
Centre d'animation, de développement et de recherche en éducation
core +6 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Production et valorisation des savoirs scientifiques sur l’éducation [PDF]
, 2014 La démarche scientifique consistant à étudier les faits éducatifs a débouché sur cette catégorie qu’on appelle « recherche en éducation ». Elle a même amené la création, avec des appellations diverses selon les pays, d’un champ universitaire qu’on ...
Gaussel, Marie
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Frontiers in CommunicationThis perspective article explores the intersection of science education advancements and public science understanding improvement efforts, critiquing the still prevalent “deficit model” of science communication.
Patrice Potvin +3 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
L’évolution d’un projet social vers un projet architectural et éducatif : le cas d’une école ouverte
Lien Social et Politiques, 2015 L’article se propose d’interroger l’élaboration d’un projet d’école ouverte depuis sa genèse jusqu’à sa mise en oeuvre. Il abordera le cas d’une commune qui, au lendemain des mouvements de « Mai 68 », fédérera de nombreux acteurs autour d’un projet d ...
Nadège Tenailleau
doaj +1 more source