Results 81 to 90 of about 3,093,684 (246)

Quelle place l’enseignement a-t-il parmi les motivations et projets professionnels des étudiants en Education physique? [PDF]

open access: yes, 2004
peer reviewedIl est commun de considérer que les études en éducation physique conduisent exclusivement à une carrière dans l’enseignement. Toutefois, les recherches portant sur les aspirations professionnelles des étudiants entrant dans ce type de ...
Carlier, Ghislain   +6 more
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Le choix de l’école secondaire de langue française en Ontario par les parents

open access: yesLien Social et Politiques, 2011
L’éducation représente une ressource centrale dans les nouvelles économies du savoir du XXIe siècle et la notion de choix scolaire est examinée ici dans le contexte de recomposition de l’État.
Nathalie Bélanger
doaj   +1 more source

L'entretien de corégulation en éducation thérapeutique du patient

open access: yes, 2014
International audienceNous nous inscrivons dans le courant de recherche en didactique professionnelle sur les relations de service. En éducation thérapeutique du patient, nous mettrons l'accent sur le travail avec un autre : le patient et sur la ...
Nagels, Marc
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Designing landscapes of affordances for ageing in place [PDF]

open access: yesGeographica Helvetica
This paper aims to contribute theoretically, methodologically, and empirically to research and interventions regarding ageing in place. Theoretically, the paper contributes by drawing on the literature on landscapes of care and landscapes of affordances ...
O. Söderström   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Contributions to a cognitive analysis of the teacher evaluation policy [PDF]

open access: yes, 2007
A definição de novas regras para a avaliação dos professores do ensino não superior acontece, em Portugal, com a publicação do Decreto‑Lei n.º 15/2007, de 19 de Janeiro.
Costa, Estela
core  

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