Results 71 to 80 of about 45,162 (243)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cinq enjeux d’évaluation face à l’émergence des IA génératives en éducation

Mesure et Évaluation en Éducation
Depuis novembre 2022, les acteurs de l’éducation s’émeuvent de l’apparition de services informatiques qui permettent de générer des textes, des images ou des sons en une simple requête.
Jacques Audran
doaj   +1 more source

Evaluation d'un enseignement par les étudiants appliquée au module à aide à la rédaction de thèse à: destiné aux internes des hôpitaux des Armées au Centre d'épidémiologie et de Santé Publique des Armées, Marseille

The Pan African Medical Journal, 2016
INTRODUCTION: en éducation, l'évaluation concerne les institutions de formation, les programmes, les enseignants ou les étudiants. Elle peut être prédictive, sommative ou formative.
Jalal Kasouati, Guillaume Velut, Xavier Deparis, Farida Touloune   +3 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Study of formative assessment in the discipline Theory and Practice of Physical Education /Estudio de la evaluación formativa en la disciplina Teoría y Práctica de la Educación Física

Podium, 2021
The evaluation as a component of the teaching-learning process has the purpose of verifying the degree of fulfillment of the objectives formulated in the plans and study programs of Higher Education; this in turn constitutes a way for feedback and ...
Maribel Mola Cantero, Marlene Concepción González Escalona, Nordis Sánchez Quintero   +2 more
doaj  

L’évaluation en 1-2 HarmoS :: quels sont les types d’évaluation retrouvés en 1-2H ? [PDF]

, 2018
De nombreuses recherches ont été menées sur les types d’évaluation retrouvés dans l’enseignement. Ayant effectué deux stages en 1ère et 2ème HarmoS, je me suis demandé quels étaient les types d’évaluation réalisés dans ces degrés. Ma recherche a pour but
Frésard, Christelle, Riat, Christine
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Évaluer autrement ? Perceptions étudiantes sur l’évaluation formative et sommative à l’université

Langues & Cultures
Cette recherche examine comment les étudiants.es de l'enseignement supérieur perçoivent et réagissent aux différentes modalités d'évaluation : formative (continue), sommative (examen final) ou hybride.
Pénélope KRYSTALLI
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source