Results 81 to 90 of about 46,944 (265)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
L'évaluation formative comme aide à l'apprentissage [PDF]
, 2017 Bien que tout un chacun soit familier avec le concept de l’évaluation formative, celle-ci se déploie différemment selon la manière dont on la conçoit et la caractérise.
Mastracci, Angela
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Proposition pour fixer un seuil de réussite dans l'évaluation des compétences lors d'un stage [PDF]
, 1999 "Essai présenté à la Faculté d'éducation en vue de l'obtention du grade de Maîtrise en enseignement (M.E.)"M.E.
Leroux, Julie Lyne +1 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
La verbalisation des procédures favorise-t-elle l'autorégulation des élèves ?
, 2013 L'objectif de ce mémoire est de savoir si la connaissance (par le biais de la verbalisation) des critères de réalisation (ou critères de procédures) permet aux élèves de s'autoréguler et de progresser.
Carre, Emmanuel, de Casas, Camille
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Formative Evaluations in Online Classes
Journal of Educators Online, 2016 Online courses are continuing to become an important component of higher education course offerings. As the number of such courses increases, the need for quality course evaluations and course improvements is also increasing.
Jennifer Peterson
doaj