Results 91 to 100 of about 8,743,550 (229)
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Effets de l'évaluation par les pairs sur les pratiques d'expression orale d'élèves de 3e secondaire : une description [PDF]
, 2008 La communication orale a longtemps été négligée dans la didactique du français. Aux cours des dernières années, la didactique de l'oral s'est beaucoup développée (Plessis-Bélair, Lafontaine et Bergeron, 2007).
Dumais, Christian
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, 2015 Cet article est soumis à une évaluation ouverte par les pairs. Les rapports d’évaluation sont ou seront postés à la suite du texte. Pour consulter les annotations faites sous hypothes.is, le plug-in est activable en cliquant sur ce lien.
Tony Rey
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Constatations en bref de l'examen externe du programme ACACIA
, 2010 Version anglaise disponible dans la Bibliothèque numérique du CRDI: External review of Acacia ProgramCe texte présente les principales constatations des rapports intitulés Acacia 2006-2010 Final Report, préparé par l'équipe du programme ACACIA en ...
CRDI. Section de l'évaluation
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Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Serie Évaluation de programme par pays
Cette évaluation fait partie d’une série d’Évaluations des programmes de pays (EPP) conduites par le Bureau de l’évaluation de la FAO. La finalité principale d’une EPP est de contribuer à mieux orienter le programme de la FAO au niveau d’un pays, afin de
FAO
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The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source