Results 111 to 120 of about 2,022,448 (287)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Índices regionales: aspectos analíticos [PDF]
Es tarea de este ensayo examinar analíticamente diversos indicadores regionales, para afrontar un “contexto de información muy limitada”, de modo tal de conocer el verdadero significado de sus potenciales valores.
Rubio, Ariel, Figueras, Alberto José
core +2 more sources
Algunas experiencias en el uso de índices limnológicos en Colombia [PDF]
, 2016 El objetivo central de este trabajo es mostrar algunas experiencias del Departamento de Biología de la Universidad Nacional de Colombia en la elaboración de índices limnológicos para evaluar el estado ecológico de sistemas acuáticos colombianos.
Pinilla Agudelo, Gabriel Antonio +2 more
core +1 more source
Integración bursátil en América Latina: un análisis de los mercados en Chile, Perú y Colombia
Lecturas de EconomíaEste artículo presenta un análisis de la integración bursátil en Latinoamérica, con un enfoque en Chile, Perú y Colombia. El objetivo principal es determinar la existencia de la integración bursátil entre ellos. Para ello, se ha probado la existencia de
Carlos Dulio Llanco Rodríguez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Índices bursátiles en Europa [PDF]
, 2014 La realización de este Trabajo Fin de Grado: "Índices bursátiles en Europa", tiene como objeto realizar un estudio descriptivo sobre 18 índices bursátiles de Europa, de los cuales 17 son índices de referencia del mercado de valores de sus respectivos ...
Martín González, Carolina
core
ColóquioA Estação da Bacia Hidrográfica do Rio Piava, em Umuarama (PR), é a única fonte de abastecimento público do município, beneficiando mais de 100 mil pessoas e assumindo, assim, um papel fundamental para a sustentabilidade da cidade. Embora de importância
Jonathan Santos Pericinoto +2 more
doaj +1 more source