Results 31 to 40 of about 24,437 (192)

A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment

Frontiers in Psychiatry, 2023
Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence.
Florence Vorspan, Florence Vorspan, Philippe Domenech, Philippe Domenech, David Grabli, David Grabli, Jérôme Yelnik, Marine Delavest, Charles Dauré, Frank Bellivier, Frank Bellivier, Antoine Pelissolo, Antoine Pelissolo, Hayat Belaid, Christelle Baunez, Carine Karachi, Carine Karachi, Luc Mallet, Luc Mallet, Luc Mallet   +19 more
doaj   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

UNICANCER: French prospective cohort study of treatment-related chronic toxicity in women with localised breast cancer (CANTO)

ESMO Open, 2019
Background Corresponding with improved survival among patients with breast cancer, the awareness of the long-term effects of cancer treatments has increased.
Patrick Arveux, Ines Vaz-Luis, Paul Cottu, Christel Mesleard, Anne Laure Martin, Agnes Dumas, Sarah Dauchy, Olivier Tredan, Christelle Levy, Johan Adnet, Marina Rousseau Tsangaris, Fabrice Andre   +11 more
doaj   +1 more source

Impact of the presence of a prosthetic implant and transition to oral stepdown therapy on relapse rates and mortality in uncomplicated Staphylococcus aureus bacteremia treated with 14 days of antibiotics: a retrospective cohort study

Microbiology Spectrum
The aim of this single-center, retrospective observational study was to evaluate the effects of having a prosthetic implant (PI) and of changing from intravenous to oral antibiotics (oral stepdown therapy [OST]) on the risk of relapse in patients with ...
Damien Blez, Luc Labarbe, Patrick Grohs, Jean-Luc Mainardi, Jean-Philippe Barnier, David Lebeaux, Marie Dubert   +6 more
doaj   +1 more source

IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment

Journal for ImmunoTherapy of Cancer, 2020
Background As the immune system is compromised in patients with cancer, therapeutic strategies to stimulate immunity appear promising, to avoid relapse and increase long-term overall survival.
Mélanie Desbois, Coralie Béal, Mélinda Charrier, Benjamin Besse, Guillaume Meurice, Nicolas Cagnard, Yannick Jacques, David Béchard, Lydie Cassard, Nathalie Chaput   +9 more
doaj   +1 more source

Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression

Arthritis &Rheumatology, EarlyView.
Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source

Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancer

Journal for ImmunoTherapy of Cancer
Background Molecular mimicry between commensal bacterial antigens and tumor-associated antigens (TAAs) has shown potential in enhancing antitumor immune responses.
Agostina Stradella, Francois Ghiringhelli, Ana Maia, Cécile Gouttefangeas, Ulrich Herrlinger, Maria Vieito, Ahmed Idbaih, Ghazaleh Tabatabai, Olivier Adotevi, Alice Talpin, Jennifer Martinez, Wolfgang Wick, Laura Boullerot, Jerome Kervevan, Lucie Aubergeon, Diana Bachrouche, Chloé Ventujol, Léa Bernard, Amandine Manteau, Christophe Bonny, Laurent Chene, Iris Mildenberger, Michael C Burger, Jean-Marie Carpier, Guillaume Kulakowski, Camille Gaal, Francesco Strozzi, Coline Billerey, Ludivine Amable, Tifanny Mersceman, Alexandrine Garnier, Càtia Oliveira, Carolina Calderon, Michaël Bonnet, Julie Noguerol, Karl Laviolette, Marine Malfroy, Gregoire Chevalier, Olivier Joffre, David A. Reardon, Joao Gamelas Magalhaes   +40 more
doaj   +1 more source

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Central nervous system tumours and occupational ionising radiation exposure: a nested case–control study among the ORICAMs cohort of healthcare workers in France

BMJ Open
Objective This study aimed at investigating the relationship between occupational exposure to external ionising radiation and central nervous system (CNS) tumours mortality in healthcare workers working in France.Design and setting The Occupational ...
Sylvaine Caër-Lorho, Klervi Leuraud, Marie-Odile Bernier, Lynda Bensefa-Colas, Julie Lopes, Clémence Baudin, Frédéric Rousseau, Hervé Roy, Philippe Lestaevel   +8 more
doaj   +1 more source