Results 51 to 60 of about 92 (92)

The Determinants of Negotiated Pharmaceutical Prices

The Journal of Industrial Economics, EarlyView.
ABSTRACT We focus on the determinants of pharmaceutical drug prices. Using data from the Brazilian pharmaceutical market, we find large variations in drug prices across buyers, drug classes, and time periods. Our estimation results provide evidence that transaction‐specific determinants between buyers and sellers (e.g., transaction volume, buyer's ...
Ralph B. Siebert, Sebastian Linde, Brandon Norton   +2 more
wiley   +1 more source

A Meta‐Analysis of Cost‐Effectiveness in Cervical Degenerative Disc Disease Treated With Cervical Disc Arthroplasty Versus Anterior Cervical Discectomy and Fusion

Orthopaedic Surgery, EarlyView.
This meta‐analysis finds that anterior cervical discectomy and fusion (ACDF) has a lower initial cost, while cervical disc arthroplasty (CDA) demonstrates a lower risk of reoperation and DVT/PE. CDA's long‐term clinical benefits may offset its higher upfront expense.
Thomas Cho, Kriti Devgan, Nipun U. Jayatissa, Hossein Elgafy, Jiayong Liu   +4 more
wiley   +1 more source

Pacing Ratio Changes of an Implanted Permanent Pacemaker After Transcatheter Aortic Valve Implantation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background In some patients, transcatheter aortic valve implantation (TAVI) is associated with conduction disturbances, necessitating permanent pacemaker implantation (PMI). The clinical course of conduction disturbances after PMI, based on the type of TAVI valve, remains unclear.
Yu Fukuoka, Yoshifumi Ikeda, Hitoshi Mori, Keisuke Matsuo, Takahide Arai, Ritsushi Kato, Shintaro Nakano, Akihiro Yoshitake, Haruka Yamazaki, Hiroki Yamazaki, Yusuke Koga   +10 more
wiley   +1 more source

Incidence and Determinants of Implantable Cardioverter‐Defibrillator Therapy With Loss of and Impaired Consciousness

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Implantable cardioverter‐defibrillators (ICDs) are important in the prevention of sudden cardiac death. However, some appropriate ICD therapies may be considered unnecessary, delivered when patients do not experience symptoms of hemodynamic instability such as loss of consciousness.
Alwin B. P. Noordman, Michiel Rienstra, Yuri Blaauw, Bart A. Mulder, Hessel Groenveld, Alexander H. Maass   +5 more
wiley   +1 more source

Long‐Term Outcomes of Radiofrequency Atrioventricular Node Ablation in a Real‐World Population

Pacing and Clinical Electrophysiology, EarlyView.
Abstract Background While interventional strategies have expanded the options for long term rhythm restoration, rate control continues to play a pivotal role in the treatment of atrial arrhythmias; however, pharmacologic strategies alone often fail in achieving effective rate control.
Vanessa Sciacca, Nora‐Kristin Brandt, Thomas Fink, Denise Guckel, Maximilian Mörsdorf, Yuri Bocchini, Martin Braun, Moneeb Khalaph, Karen Harutyunyan, Nadica Trajkovska, Philipp Lucas, Thomas Eitz, Maxim Didenko, Philipp Sommer, Christian Sohns   +14 more
wiley   +1 more source

QT Interval Evaluation in Right Ventricular Pacing: Validation of a Novel Formula

Pacing and Clinical Electrophysiology, EarlyView.
Abstract Background QT interval measurement in the presence of right ventricular pacing (RVP) represents a clinical challenge. We therefore aimed to derive and validate a formula for QT estimation during RVP in a large cohort of pacemaker patients. Methods and Results We prospectively enrolled 100 patients in a derivation cohort and 487 in a validation
Amr Abdin, Alhasan Almasri, Ibrahim Antoun, Charles Gieres, Christian Werner, Yvonne Bewarder, Christian Ukena, Igor Schwantke, Michael Böhm, Saarraaken Kulenthiran   +9 more
wiley   +1 more source

Werner Irnich: Pioneer in the Development of the Dual‐Chamber Pacemaker—An Obituary

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Fifty years ago, Werner Irnich presented the concept of an optimal pacemaker capable of responding appropriately to various cardiac arrhythmias and perceptual disturbances, and intended to be used in 85% of patients. With this concept, Irnich was far ahead of his time. His proposed circuitry for AV block and atrial fibrillation, as well as his
Bernd Lemke
wiley   +1 more source

Chemical treatment rescues reduced growth of the autoimmune mutant chs3‐2D without compromising its immune responses

Plant Biology, EarlyView.
We generated a compound by chemical modification that can efficiently rescue growth without decreasing the immune response of the chs3‐2D autoimmune mutants, thus chemically uncoupling its growth–defence trade‐off. Abstract Plant development in many species including Arabidopsis relies on the accurate balance between growth and defence.
M. Keijzer, M. Liebers, J. Seufer, L. Voll, C. Meier, S. Hoth   +5 more
wiley   +1 more source

Ecological restoration hierarchy as a lens to reveal the foundational economic and legal structures impeding restoration

Restoration Ecology, EarlyView.
Abstract Introduction Biodiversity loss is accelerating due to habitat destruction, economic expansion, and insufficient conservation efforts. Traditional mitigation strategies, which focus on minimizing harm rather than reversing damage, are inadequate for achieving net biodiversity gain. Objectives This article introduces the restoration hierarchy, a
Niko Soininen, Suvi‐Tuuli Puharinen, Antti Iho, Saija Koljonen, Janne Artell, Kimmo Tolonen, Antti Belinskij   +6 more
wiley   +1 more source

Health effects of a youth labor market activation policy

The Scandinavian Journal of Economics, EarlyView.
Abstract We examine the health effects of a labor market activation policy in Sweden, the Youth Job Guarantee. To estimate causal effects, we implement a regression discontinuity design using the policy's age‐eligibility threshold, together with detailed administrative data on health‐related outcomes, including indicators of mental health.
Caroline Hall, Kaisa Kotakorpi, Linus Liljeberg, Jukka Pirttilä   +3 more
wiley   +1 more source