Results 151 to 160 of about 6,074,365 (251)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ðнализ и поиÑк пÑÑей повÑÑÐµÐ½Ð¸Ñ Ð¿ÑибÑли и ÑенÑабелÑноÑÑи пÑедпÑиÑÑÐ¸Ñ (на пÑимеÑе ÐР«ÐÑмалиÑ»)

, 2017
Анастасия Владимировна Толстова
openalex   +1 more source

Patient satisfaction with infection prevention and control interventions in acute hospitals: a systematic review and meta-analysis. [PDF]

BMJ Open
Skally M, Kearney A, Strawbridge J, Heritage J, Cox C, Bennett KE, Humpreys H, Fitzpatrick F.   +7 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

ÐÐРÐÐÐЯÐÐЯ ÐФÐÐТÐÐÐÐСТРСТÐÐÐÐРТÐÐÐ¥ ТРÐÐÐÐРÐЧÐÐÐ¥ РÐÐÐÐÐРХÐÐÐÐТÐРÐÐÐÐ ÐÐЯ 4-Ñ ÐÐÐÐÐЧÐÐÐ ÐÐТÐÐÐРÐÐ ÐÐЦÐÐÐТÐÐ Ð ÐÐСÐÐÐРРÐÐÐÐÐÐ ÐУÐЬТÐРÐÐÐСТÐÐТÐÐÐРТУÐÐРÐУÐЬÐÐУ

, 2013
Н.А. Литвиненко, С.О. Черенько, Л.М. Циганкова, Я.В. Вольський, О.Р. Тарасенко   +4 more
openalex   +2 more sources

High gain non-isolated step-up DC-DC converter proper for renewable energy applications. [PDF]

Sci Rep
Rostami R, Hosseini SH, Sharifian MBB.
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

ÐÑпекÑÑ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑики и леÑÐµÐ½Ð¸Ñ ÑиÑÑÑгиÑеÑÐºÐ¸Ñ Ð³Ð½Ð¾Ð¹Ð½Ð¾-ÑепÑиÑеÑÐºÐ¸Ñ Ð¾Ñложнений пÑи вÑоÑиÑном иммÑнодеÑиÑиÑе.

, 2013
А. И. Краснослободский
openalex   +2 more sources

Sex-Specific Association Between Vitamin D Insufficiency and Burning Pain in Herpetic Neuralgia: A Prospective Cohort Study. [PDF]

J Pain Res
Zhao W, Li Z, Ju J, Liu J, Peng X, Chu T, Ren J, Tu Y, Gao F.   +8 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source