Results 91 to 100 of about 6,270,976 (255)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

High-risk newborns and pervasive developmental disorders [PDF]

, 2017
Aim of the paper: Analysis of developmental abilities in high-risk infants, with an emphasis on risk, early screening and early diagnosis of disorders of the autistic spectrum (ASD).
Dukovska, Valentina, Duma, Filip, Popovska, Ana, Zorcec, Tatjana   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Semisimple strata for p-adic classical groups [PDF]

, 2002
Let F0 be a non-archimedean local field, of residual characteristic different from 2, and let G be a unitary, symplectic or orthogonal group defined over F0.
Stevens, S
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Pofessor D. J. van Rooy- 'n waardering

Koers : Bulletin for Christian Scholarship, 1956
So ken ons vir Dirk Jan van Rooy. Deur sy wysheid is hy ’n toring van krag in elke kring waarin hy hom beweeg.
W. P. Robbertse
doaj   +1 more source

Walking along the oldest human fossil pathway (Roccamonfina volcano, Central Italy)? [PDF]

, 2017
Here we report the remarkable superposition of a pre-historic trackway (349–350 ± 3 ka) with one used in more recent historical times, potentially forming one of the oldest path or trackways currently known. A Plinian eruption of the Roccamonfina Volcano
Bennett, Matthew R., Farinaro, G., Mietto, P., Panarello, A., Santello, L.   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Supporting different search strategies in a video query interface [PDF]

, 2000
This paper reports the design and development of the Diceman Query Application.
Dunlop, M.D., McDonald, K.
core   +2 more sources