Results 21 to 30 of about 255,920 (186)

Suplementacao de omega 3 em pessoas com epilepsia submetidas a um programa regular de hemidialise: veio para ficar [PDF]

, 2013
Among the many risk factors suggested for sudden unexpected death in epilepsy (SUDEP), higher frequency of seizures is a very consistent issue. Furthermore, it has been established that hemodialysis-associated seizure is a complication of the dialysis ...
Arida, Ricardo Mario, Cavalheiro, Esper Abrão, Cysneiros, Roberta Monterazzo, Scorza, Carla Alessandra, Scorza, Fulvio Alexandre   +4 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Ácidos graxos poli-insaturados na regulação das concentrações séricas de triglicerídeos e ácidos graxos não esterificados em três gerações de ratos wistar. [PDF]

, 2013
O objetivo deste estudo foi avaliar o efeito de dietas contendo AGPIs ômega-3 e ômega-6 nas concentrações séricas de ácidos graxos não esterificados (AGNE) e triglicerídeos (TG), no período pré e pós-parto de ratas Wistar, ao longo de três ...
CORRÊA, M. N., DEL PINO, F. A. B., FENSTERSEIFER, S. R., HALFEN, S., JACOMETO, C. B., SCHMITT, E.   +5 more
core  

Workshop on meibomian gland dysfunction [PDF]

, 2011
Federal University of São Paulo Department of OphthalmologyUniversidade de São Paulo epartment of Ophthalmology, Otorhinolaryngology, and Head and Neck SurgerySchepens Eye Research InstituteHarvard Medical School Department of OphthalmologyTear Film ...
FREITAS, Denise de, GOMES, José Álvaro Pereira, ROCHA, Eduardo M., SULLIVAN, David A.   +3 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sacha inchi na nutrição de juvenis de tambaqui e matrinxã. [PDF]

, 2019
O objetivo desta pesquisa foi avaliar a Sacha inchi Plukenetia volubilis - planta cultivada na Amazônia cujas sementes apresentam características interessantes como um adequado nível proteico (24 a 29 %), vitaminas A e E e ácidos graxos polinsaturados da
CHAVES, F. C. M., DAIRIKI, J. K., SILVA, T. B. A. da   +2 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Efeito de dietas contendo diferentes proporções de AGPIS no ganho de peso de ratos em sucessivas gerações. [PDF]

, 2013
O objetivo deste estudo foi avaliar o efeito de dietas com diferentes proporções de ácidos graxos poli-insaturados (AGPIs) ômega-3:ômega-6 no peso ao nascimento, peso ao desmame e ganho de peso médio dos filhotes de ratas Wistar/UFPel em sucessivas ...
ACOSTA, D. A. V., CORREA, M. N., DEL PINO, F. A. B., JACOMETO, C. B., PEREIRA, R. A., SCHMITT, E.   +5 more
core  

Cognitive deficit: another complication of diabetes mellitus? [PDF]

, 2008
As the population getting older, the chronic diseases will be more prevalent as diabetes mellitus (DM) and diseases characterized by cognitive deficits, as dementia.
Almada Filho, Clineu De M., Almeida-pititto, Bianca De, Cendoroglo, Maysa Seabra   +2 more
core   +2 more sources