Results 1 to 10 of about 1,298,122 (296)
Nature Nanotechnology, 2020 CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that
Qiang Cheng +5 more
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CRISPR-Cas-Based Antimicrobials: Design, Challenges, and Bacterial Mechanisms of Resistance
ACS Infectious Diseases, 2023 The emergence of antibiotic-resistant bacterial strains is a source of public health concern across the globe. As the discovery of new conventional antibiotics has stalled significantly over the past decade, there is an urgency to develop novel ...
Arianna Mayorga-Ramos +4 more
semanticscholar +1 more source
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing.
Molecules and Cells, 2021 Compact and versatile CRISPR-Cas systems will enable genome engineering applications through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient miniature Cas system (CasMINI) engineered from the type V-F Cas12f (Cas14 ...
Xiaoshu Xu +6 more
semanticscholar +1 more source
Ars & Humanitas, 2012 Bontempellijevo delo na področju pripovedništva, esejistike in publicistike zaznamujeta zavračanje relativizma ter zahteva po novih ontoloških in estetskih temeljih znotraj kulture, ki je pripravljena v isti meri preseči tako poznoromantično kot tudi ...
Patrizia Farinelli
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Non-linear analysis of two-layer timber beams considering interlayer slip and uplift [PDF]
, 2010 A new mathematical model and its finite element formulation for the non-linear analysis of mechanical behaviour of a two-layer timber planar beam is presented. A modified principle of virtual work is employed in formulating the finite element method. The
A. Kroflič +27 more
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CRISPR/Cas-mediated plant genome editing: outstanding challenges a decade after implementation.
Trends in Plant Science, 2023 The discovery of the CRISPR/Cas genome-editing system has revolutionized our understanding of the plant genome. CRISPR/Cas has been used for over a decade to modify plant genomes for the study of specific genes and biosynthetic pathways as well as to ...
T. Cardi +21 more
semanticscholar +1 more source
An analytical model of layered continuous beams with partial interaction [PDF]
, 2006 Starting with the geometrically non-linear formulation and the subsequent linearization, this paper presents a consistent formulation of the exact mechanical analysis of geometrically and materially linear three-layer continuous planar beams.
Planinc, Igor +4 more
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Nature Biotechnology, 2020 Applications of adenine base editors (ABEs) have been constrained by the limited compatibility of the deoxyadenosine deaminase component with Cas homologs other than SpCas9.
M. Richter +11 more
semanticscholar +1 more source
Locking-free two-layer Timoshenko beam element with interlayer slip [PDF]
, 2007 A new locking-free strain-based finite element formulation for the numerical treatment of linear static analysis of two-layer planar composite beams with interlayer slip is proposed.
Ayoub +29 more
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Spektakel in čas v sodobni filozofiji [PDF]
Phainomena, 2023 Spectacle and Time in Contemporary Philosophy Through historical and phenomenological analyses, the present paper attempts to centralize the research of the phenomenon of spectacle as a viable subject of contemporary philosophy. We study the notion of
Dario Vuger
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