Results 131 to 140 of about 1,298,122 (296)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The effect of accumulation reservoir on dynamic behaviour of concrete gravity dam Suhorka [PDF]

open access: yes, 2013
The present thesis deals with the influence of accumulation reservoir on dynamic behavior of concrete gravity dam Suhorka. In the first part of the thesis a theoretical framework is given for analyzing the influence of accumulation reservoir on natural ...
Trošt, Simon
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Optical Field Calculations in GP-GPU [PDF]

open access: yes, 2012
Tato práce popisuje poměrně novou techniku určenou na psaní vysoko paralelních programů, které název je OpenCL. Je určena jak pro GPU, tak i pro CPU a jiné paralelní procesory. Knižnice využívá architekturu procesoru, která obsahuje velké množství malých
Srnec, Erik
core  

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

open access: yesNature Reviews Microbiology, 2019
K. Makarova   +25 more
semanticscholar   +1 more source

Monkeypox Knowledge and Vaccine Hesitancy of Czech Healthcare Workers: A Health Belief Model (HBM)-Based Study. [PDF]

open access: yesVaccines (Basel), 2022
Riad A   +7 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Moon timber - myth or reality [PDF]

open access: yes, 2017
Znanost ni mogla potrditi pozornost zbujajočih lastnosti "lunarnega" lesa, tj.lesa, posekanega ob "pravem času", kot ga "narekujejo" lunine mene, zodiaška znamenja in presenetljivi fiksni termini. Lunarni les naj bi imel posebne oz.
Torelli, Niko
core  

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