Results 271 to 280 of about 81,581 (293)

In vitro α-amylase and α-glucosidase enzyme inhibition and antioxidant activity by capsaicin and piperine from Capsicum chinense and Piper nigrum fruits

Journal of Environmental Science and Health. Part B - Pesticides, Food Contaminants, and Agricultural Wastes, 2021
In the present study, α-amylase and α-glucosidase inhibitory effect and antioxidant activity of capsaicin and piperine from the ethanolic extract of Capsicum chinense (EECch) and Piper nigrum (EEPn) fruits were investigated.
E. Magaña-Barajas, G. V. Buitimea-Cantúa, A. Hernández‐Morales, V. R. Torres-Pelayo, J. Vázquez-Martínez, N. E. Buitimea‐Cantúa   +5 more
semanticscholar   +1 more source

Inhibition Mechanism of α-Amylase/α-Glucosidase by Silibinin, Its Synergism with Acarbose, and the Effect of Milk Proteins.

Journal of Agricultural and Food Chemistry, 2021
As a natural flavonolignan, silibinin is reported to possess multiple biological activities, while the inhibitory potential of silibinin on carbohydrate-hydrolyzing enzymes is still unclear.
Jichen Yang, Huan Li, Xiaoli Wang, Chuanying Zhang, G. Feng, Xin Peng   +5 more
semanticscholar   +1 more source

Molecular modeling, docking and dynamics studies of fenugreek (Trigonella foenum-graecum) α-amylase

Journal of Biomolecular Structure and Dynamics, 2022
α-Amylase catalyses the hydrolysis of glucosidic bonds in polysaccharides such as starch, glycogen and their degradation products. In the present study, the three-dimensional structure of fenugreek (Trigonella foenum-graecum) α-amylase was determined ...
Avinash Kumar, V. K. Singh, A. Kayastha
semanticscholar   +1 more source

In vitro and in silico studies of fluorinated 2,3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents

Archiv der Pharmazie, 2021
As part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the condensation of 3‐(aryl/benzyloxyaryl)‐pyrazole‐4‐carbaldehydes with ...
D. Ganavi, R. Ramu, Vasantha Kumar, Shashank M. Patil, R. M. Martiz, Prithvi S Shirahatti, Reshma Sathyanarayana, B. Poojary, B. S. Holla, Vishwanatha Poojary, K. Kumari, Jagadeep Chandra Shivachandra   +11 more
semanticscholar   +1 more source

Inhibition of α‐glucosidase and α‐amylase by herbal compounds for the treatment of type 2 diabetes: A validation of in silico reverse docking with in vitro enzyme assays

Journal of Diabetes, 2021
α‐Amylase and α‐glucosidase are important therapeutic targets for the management of type 2 diabetes mellitus. The inhibition of these enzymes decreases postprandial hyperglycemia.
M. Tolmie, M. Bester, Z. Apostolides
semanticscholar   +1 more source

The inhibitory effects of flavonoids on α-amylase and α-glucosidase

Critical reviews in food science and nutrition, 2020
The objective of this review is to summarize knowledge on the inhibitory effects (IEs) of flavonoids on α-amylase (αA) and α-glucosidase (αG) relevant to the search of substitutes of acarbose (Aca).
Jianzhong Zhu, Chun Chen, Bin Zhang, Qiang Huang   +3 more
semanticscholar   +1 more source

A brief overview on the application and sources of α‐amylase and expression hosts properties in order to production of recombinant α‐amylase

Biotechnology and applied biochemistry, 2021
By reducing the activation energy, enzymes accelerate the chemical reaction; therefore, they are good alternative for industrial catalysts. Amylase is a suitable enzyme as a catalyst for the chemical decomposition of starch.
A. Movahedpour, M. Asadi, S. H. Khatami, M. Taheri‐Anganeh, M. Adelipour, Zahra Shabaninejad, Nahid Ahmadi, Cambyz Irajie, P. Mousavi   +8 more
semanticscholar   +1 more source

Molecular dynamics simulation for screening phytochemicals as α-amylase inhibitors from medicinal plants

Journal of Biomolecular Structure and Dynamics, 2020
Diabetes mellitus (DM) is a complicated metabolic disorder with several enzymes, including α-amylase and α-glycosidase. The α-amylase is responsible for postprandial glucose levels; therefore, inhibiting its activity is helpful in diabetes management ...
Priyanka Sharma, T. Joshi, Tanuja Joshi, S. Chandra, S. Tamta   +4 more
semanticscholar   +1 more source

Antidiabetic properties of dietary phenolic compounds: Inhibition effects on α‐amylase, aldose reductase, and α‐glycosidase

Biotechnology and applied biochemistry, 2019
Aldose reductase (AR), α‐amylase, and α‐glycosidase are vital enzymes to prevent diabetic complications. Here, AR was purified from sheep kidney using elementary methods with 111.11‐purification fold and with 0.85% purification yield.
Yeliz Demir, Lokman Durmaz, Parham Taslimi, I. Gulcin   +3 more
semanticscholar   +1 more source

Biosynthesis and industrial applications of α-amylase: a review

Archives of Microbiology, 2021
M. A. Farooq, Sajid Ali, A. Hassan, H. M. Tahir, S. Mumtaz, Shumaila Mumtaz   +5 more
semanticscholar   +1 more source