Results 1 to 10 of about 36,507 (220)

PGC-1a in muscle links metabolism to inflammation [PDF]

, 2009
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life ...
Handschin, C.
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

On the Zweier Sequence Spaces of Fuzzy Numbers

International Journal of Mathematics and Mathematical Sciences, 2014
It was given a prototype constructing a new sequence space of fuzzy numbers by means of the matrix domain of a particular limitation method. That is we have constructed the Zweier sequence spaces of fuzzy numbers [ℓ∞(F)]Zη, [c(F)]Zη, and [c0(F)]Zη ...
Mehmet Şengönül
doaj   +1 more source

Trans-Selective Conversions of γ-Hydroxy-α,β-Alkynoic Esters to γ-Hydroxy-α,β-Alkenoic Esters

, 2016
γ-Hydroxy-α,β-acetylenic esters are used as precursors to prepare γ-hydroxy-α,β-alkenoic esters by means of trans-selective additions of two hydrogen atoms or one hydrogen atom and one iodine atom across the triple bonds.
Christopher T. Meta (2716702), Kazunori Koide (779946)   +1 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

On Some New Generalized Difference Sequence Spaces of Nonabsolute Type

Journal of Mathematics, 2014
We define a new triangle matrix W^=(wnkλ) by the composition of the matrices Λ=(λnk) and B(r,s,t). Also, we introduce the sequence spaces c0λ(B^),cλ(B^),l∞λ(B^), and lpλ(B^) by using matrix domain of the matrix W^ on the classical sequence spaces c0,c,l∞,
Osman Duyar, Serkan Demiriz, Osman Özdemir   +2 more
doaj   +1 more source

β-Halo-α,β-unsaturated γ-Sultones

, 2016
The reaction of β-iodo-α,β-unsaturated γ-sultones (i.e., 4-halo-1,2-oxathiole 2,2-dioxides) in aprotic polar solvents such as DMSO or acetone, with ‘soft' nucleophiles such as iodide or thioacetate, yields an allenesulfonate by a very facile halophilic ...
Tatiana Pechenick-Azizi (2478478), Dan T. Major (1484047), Samuel Braverman (2478472), Milon Sprecher (2478475)   +3 more
core   +1 more source

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines [PDF]

, 2012
The asymmetric synthesis of new chiral γ-chloro-α,β-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene)glycinamides across chiral α-chloro-N-p-toluenesulfinylaldimines was developed. The resulting
Gert Callebaut, Tornroos, Karl W., Van der Veken, Pieter, Sven Mangelinckx, Mangelinckx, SvenLA240019960368968010015936850000-0002-9349-880XF65B9272-F0ED-11E1-A9DE-61C894A0A6B4, Pieter Van der Veken, Callebaut, Gert, De Kimpe, Norbert, Callebaut, GertUGent0020041096238020006516539786512120510AC8883C-F0EE-11E1-A9DE-61C894A0A6B4, Mangelinckx, Sven, Koen Augustyns, Norbert De Kimpe, De Kimpe, NorbertUGent801000520827978899405446F418046E-F0ED-11E1-A9DE-61C894A0A6B4, Karl W. Törnroos, Tornroos, Karl W, Augustyns, Koen   +15 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Copper Lacus Sequence Spaces Associated With Operator Ideals and Their Geometric Properties

Journal of Mathematics
In this research, we introduce the regular Copper Lucas matrix operator, which is based on the Copper Lucas sequence. We investigate the sequence spaces c0Γ and cΓ, as well as lpΓ for 1≤p≤∞, all of which are linked to the newly defined regular Copper ...
Shiva Shah, Bipan Hazarika, Awd Bkri, Runda A. A. Bashir   +3 more
doaj   +1 more source