Results 1 to 10 of about 21,437 (100)

Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones [PDF]

Heliyon, 2022
The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose.
Mardi Santoso, Li Lin Ong, Nur Pasca Aijijiyah, First Ambar Wati, Azminah Azminah, Rose Malina Annuur, Arif Fadlan, Zaher M.A. Judeh   +7 more
doaj   +2 more sources

Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. Taking into account the significance of these moieties, we herein present the synthesis, single-crystal X-ray analysis, DFT studies ...
Bilal Ahmad Khan, Syeda Shamila Hamdani, Muhammad Naeem Ahmed, Shahid Hameed, Muhammad Ashfaq, Ahmed M. Shawky, Mahmoud A. A. Ibrahim, Peter A. Sidhom   +7 more
doaj   +2 more sources

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

Molecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C. Cruz-López, Fabiola E. Jiménez-Montejo, Víctor E. López y López, Carlos H. Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz, Aarón Mendieta-Moctezuma   +10 more
doaj   +1 more source

Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys [PDF]

Journal of Nephropharmacology, 2022
Introduction: In most ancient cultures, honey has been used for both nutritional and medical purposes. Objectives: In this research, phenolic extracts of four Iranian honeys were evaluated to determine the antioxidant potentials using DPPH (2,2-diphenyl ...
Mahmoodreza Moein, Soheila Moein, Fatemeh Farmani, Sahere Rozbehan, Zahra Sabahi   +4 more
doaj   +1 more source

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors

Frontiers in Chemistry, 2022
A series of benzylidene analogs of oleanolic acid 4a∼4s were synthesized and assessed for their α-glucosidase and α-amylase inhibitory activities. The results presented that all synthesized analogs exhibited excellent-to-moderate inhibitory effects on α ...
Jun-Jie Ke, Jing Lin, Xin Zhang, Xiao-Zheng Wu, Ying-Ying Zheng, Chun-Mei Hu, Yu Kang, Kun Zhang, Zhuang Xiong, Zhi-Qiang Ma   +9 more
doaj   +1 more source

In vitro, in silico and Pharmaco-toxicological Efficiencies of some Triazole Derivatives on Inhibition of Digestive Enzyme Alpha-amylase

Brazilian Archives of Biology and Technology, 2022
Obesity is one of the main health problems associated with a range of diseases. Genetic disposition is related to the risk for obesity but external conditions such lifestyle also increase the incidence.
Elif Ayazoglu Demir, Ahmet Colak, Selcen Celik Uzuner, Ahmet Yasar, Olcay Bekircan, Aylin Kabahasanoglu   +5 more
doaj   +1 more source

Effect of Black Tea and Black Tea Pomace Polyphenols on α-Glucosidase and α-Amylase Inhibition, Relevant to Type 2 Diabetes Prevention [PDF]

Frontiers in Nutrition, 2015
This study evaluates the potential mechanism of action and bioactivity of black tea and black tea pomace for type 2 diabetes prevention via inhibition of carbohydrate hydrolyzing enzymes. Black tea leaves were extracted in hot water and black tea pomace was extracted in 70% acetone.
Lisa eStriegel, Lisa eStriegel, Bouhee eKang, Sarah J. Pilkenton, Michael eRychlik, Emmanouil eApostolidis   +5 more
openaire   +4 more sources

Inhibition Effect and Molecular Mechanism of Tea Polyphenols on the α-Amylase

Shipin gongye ke-ji, 2022
In present study, the inhibitory effect and molecular mechanism of tea polyphenols on α-amylase were investigated. With the determination of inhibition kinetics, the inhibition of tea polyphenols on α-amylase was estimated.
Hongtu ZHANG, Weijin DONG, Nan CHEN, Qianda XU, Haoxiang GAO, Qiang HE, Weicai ZENG   +6 more
doaj   +1 more source

The Physical Adsorption of Gelatinized Starch with Tannic Acid Decreases the Inhibitory Activity of the Polyphenol against α-Amylase

Foods, 2021
The effects of mixing orders of tannic acid (TA), starch, and α-amylase on the enzyme inhibition of TA were studied, including mixing TA with α-amylase before starch addition (order 1), mixing TA with pre-gelatinized starch before α-amylase addition ...
Yueyi Wang, Shuangshuang Li, Fangting Bai, Junwei Cao, Lijun Sun   +4 more
doaj   +1 more source

ANTI-DIABETIC POTENTIAL OF PEPTIDE FROM P. NIRURI REVEALS THROUGH CARBOHYDRATE HYDROLYZING ENZYME INHIBITION ASSAY [PDF]

Science Heritage Journal, 2019
Herb Phyllanthus niruri (P. niruri) is known to have various pharmacological functions including anti-diabetic properties. In this research, protein extracts from different plant parts (leave, fruit and stem) of P. niruri were investigated for their anti-
Noor Hasniza Md Zin, Ainul Mardhiah Mohd Nail   +1 more
doaj   +1 more source