Results 1 to 10 of about 146,148 (156)

Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones [PDF]

Heliyon, 2022
The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose.
Mardi Santoso, Li Lin Ong, Nur Pasca Aijijiyah, First Ambar Wati, Azminah Azminah, Rose Malina Annuur, Arif Fadlan, Zaher M.A. Judeh   +7 more
doaj   +3 more sources

Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. Taking into account the significance of these moieties, we herein present the synthesis, single-crystal X-ray analysis, DFT studies ...
Bilal Ahmad Khan, Syeda Shamila Hamdani, Muhammad Naeem Ahmed, Shahid Hameed, Muhammad Ashfaq, Ahmed M. Shawky, Mahmoud A. A. Ibrahim, Peter A. Sidhom   +7 more
doaj   +3 more sources

HPLC-DAD-MS Characterization, Antioxidant Activity, α-amylase Inhibition, Molecular Docking, and ADMET of Flavonoids from Fenugreek Seeds [PDF]

Molecules, 2023
Fenugreek (Trigonella foenum-graecum) has a great beneficial health effect; it has been used in traditional medicine by many cultures. Likewise, the α-amylase inhibitors are potential compounds in the development of drugs for the treatment of diabetes ...
Mohammed Lamine Khenifi, Talia Serseg, Piotr Migas, Mirosława Krauze-Baranowska, Sadin Özdemir, Chawki Bensouici, Mohammed I. Alghonaim, Khattab Al-Khafaji, Sulaiman A. Alsalamah, Messaoud Boudjeniba, Mohamed Yousfi, Fehmi Boufahja, Hamdi Bendif, Mohamed Mahdid   +13 more
doaj   +3 more sources

Phytochemical Profile, α-Glucosidase, and α-Amylase Inhibition Potential and Toxicity Evaluation of Extracts from Citrus aurantium (L) Peel, a Valuable By-Product from Northeastern Morocco. [PDF]

Biomolecules, 2021
Due to the high volume of peel produced, Citrus by-product processing could be a significant source of phenolic compounds, in addition to essential oil.
Benayad O, Bouhrim M, Tiji S, Kharchoufa L, Addi M, Drouet S, Hano C, Lorenzo JM, Bendaha H, Bnouham M, Mimouni M.   +10 more
europepmc   +2 more sources

Phytochemical screening, anti-oxidant activity and α-amylase inhibition study using different extracts of loquat (Eriobotrya japonica) leaves. [PDF]

Heliyon, 2020
Diabetes Mellitus is an endocrine disorder which causes insulin deficiency. Medicinal plants are documented to be efficacious in the management of the disease.
Mogole L, Omwoyo W, Mtunzi F.
europepmc   +2 more sources

Bio-Guided Fractionation Driven by In Vitro α-Amylase Inhibition Assays of Essential Oils Bearing Specialized Metabolites with Potential Hypoglycemic Activity. [PDF]

Plants (Basel), 2020
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by unpaired blood glycaemia maintenance. T2DM can be treated by inhibiting carbohydrate hydrolyzing enzymes (α-amylases and α-glucosidases) to decrease postprandial hyperglycemia ...
Capetti F, Cagliero C, Marengo A, Bicchi C, Rubiolo P, Sgorbini B.   +5 more
europepmc   +2 more sources

Forty-One Plant Extracts Screened for Dual Antidiabetic and Antioxidant Functions: Evaluating the Types of Correlation between -Amylase Inhibition and Free Radical Scavenging. [PDF]

Molecules, 2021
Dysregulation of glucose homeostasis followed by chronic hyperglycemia is a hallmark of diabetes mellitus (DM), a disease spreading as a worldwide pandemic for which there is no satisfactory dietary treatment or cure.
Bashkin A, Ghanim M, Abu-Farich B, Rayan M, Miari R, Srouji S, Rayan A, Falah M.   +7 more
europepmc   +2 more sources

Effect of Black Tea and Black Tea Pomace Polyphenols on α-Glucosidase and α-Amylase Inhibition, Relevant to Type 2 Diabetes Prevention [PDF]

Frontiers in Nutrition, 2015
This study evaluates the potential mechanism of action and bioactivity of black tea and black tea pomace for type 2 diabetes prevention via inhibition of carbohydrate hydrolyzing enzymes. Black tea leaves were extracted in hot water and black tea pomace was extracted in 70% acetone.
Lisa eStriegel, Lisa eStriegel, Bouhee eKang, Sarah J. Pilkenton, Michael eRychlik, Emmanouil eApostolidis   +5 more
openaire   +5 more sources

In Vitro α-Amylase Inhibition and Antioxidant Activities of Methanolic Extract of Amaranthus Caudatus Linn

Oman Medical Journal, 2011
Objectives: The present study was aimed to investigate the α-amylase inhibition and antioxidant activities of methanolic extract of Amaranthus caudatus Linn (MeAc).Methods: Methanolic extract of Amaranthus caudatus was screened for α-amylase inhibition ...
Ashok Kumar BS, Lakshman K, Jayaveera KN, Sheshadri Shekar D, Narayan Swamy VB, Saleemulla Khan, Velumurga C   +6 more
doaj   +2 more sources

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors

Molecules, 2023
Current antidiabetic drugs have severe side effects, which may be minimized by new selective molecules that strongly inhibit α-glucosidase and weakly inhibit α-amylase.
Dolores G. Aguila-Muñoz, Gabriel Vázquez-Lira, Erika Sarmiento-Tlale, María C. Cruz-López, Fabiola E. Jiménez-Montejo, Víctor E. López y López, Carlos H. Escalante, Dulce Andrade-Pavón, Omar Gómez-García, Joaquín Tamariz, Aarón Mendieta-Moctezuma   +10 more
doaj   +1 more source