Results 121 to 130 of about 146,148 (156)

Design, synthesis, α-amylase inhibition and in silico docking study of novel quinoline bearing proline derivatives

, 2020
α-amylase enzyme hydrolyses carbohydrate into glucose is known to be an important molecular target for type 2 Diabetes mellitus. In the course of developing α-amylase enzyme inhibitors, we designed, synthesized seventeen novel quinoline bearing proline ...
M. S. Ganesan, K. K. Raja, K. Narasimhan, S. Murugesan, B. K. Kumar   +4 more
semanticscholar   +1 more source

Studies on α-amylase inhibition by acarbose and quercetin using fluorescence, circular dichroism, docking, and dynamics simulations.

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy
This study looked at the effects of acarbose (ACA) and quercetin (QUE) on α-amylase activity, employing QUE and ACA to measure enzyme activity. The study observed that both drugs suppressed α-amylase activity, with greater inhibition reported at higher ...
Avinash Kumar, Vinay Kumar Singh, A. Kayastha   +2 more
semanticscholar   +1 more source

The antioxidant property and α-amylase inhibition activity of young apple polyphenols are related with apple varieties

LWT, 2019
In this study, compositional profile, antioxidant activities and α-amylase inhibition of young apple polyphenols (YAP) from five cultivars (Short-branch Fuji, Pink Lady, Jinshiji, Ruiyang and Qinyang) were investigated.
Ting Zhao, Lijun Sun, Zi-Chao Wang, Tanzeela Nisar, Tian Gong, Dan Li, Pengfei Niu, Yurong Guo   +7 more
semanticscholar   +1 more source

Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis

Phytochemistry Letters, 2019
Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its ...
Chu Chu, Tuo Li, H. Pedersen, K. T. Kongstad, Jizhong Yan, D. Staerk   +5 more
semanticscholar   +1 more source

The involvement of phenolic-rich extracts from Galician autochthonous extra-virgin olive oils against the α-glucosidase and α-amylase inhibition.

Food Research International, 2019
'Brava' and 'Mansa de Figueiredo' extra-virgin olive oils (EVOOs) are two varieties identified from north-western Spain. A systematic phenolic characterization of the studied oils was undertaken by LC-ESI-IT-MS.
M. Figueiredo-González, P. Reboredo-Rodríguez, C. González-Barreiro, A. Carrasco-Pancorbo, B. Cancho-Grande, J. Simal-Gandara   +5 more
semanticscholar   +1 more source

Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibition.

Bioorganic chemistry (Print), 2021
Lalitha Gummidi, Nagaraju Kerru, O. Ebenezer, Paul Awolade, O. Sanni, M. Islam, Parvesh Singh   +6 more
semanticscholar   +1 more source

Design, synthesis of coumarin tethered 1,2,3-triazoles analogues, evaluation of their antimicrobial and α-amylase inhibition activities

Proceedings of the Indian Academy of sciences. Chemical sciences, 2021
Vagish Channabasappa, Karthik Kumara, Ajay Kumar Kariyappa   +2 more
semanticscholar   +1 more source

α-Glucosidase and α-amylase inhibition, molecular modeling and pharmacokinetic studies of new quinazolinone-1,2,3-triazole-acetamide derivatives

, 2021
A. Yavari, M. Mohammadi‐Khanaposhtani, S. Moradi, S. Bahadorikhalili, Roghayeh Pourbagher, Nasrin Jafari, M. Faramarzi, E. Zabihi, M. Mahdavi, M. Biglar, B. Larijani, H. Hamedifar, Mirhamed Hajimiri   +12 more
semanticscholar   +1 more source

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives

Medicinal Chemistry Research, 2019
M. Taha, Tayyaba Noreen, Syahrul Imran, Fasial Nawaz, Sridevi Chigurupati, Manikandan Selvaraj, F. Rahim, Nor Hadiani Ismail, Ashok Kumar, Ashik Mosaddik, Abdullah M. Alghamdi, Yousif Abdulrahman nasser alqahtani, Abdulaziz Abdulrahman nasser alqahtani   +12 more
semanticscholar   +1 more source

Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: α-Glucosidase and α-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.

Journal of Agricultural and Food Chemistry, 2017
Hua Sun, Dong Wang, Xiaotong Song, Yazhou Zhang, Weina Ding, Xiaolin Peng, Xiaoting Zhang, Yashan Li, Ying-Hong Ma, Runling Wang, Peng Yu   +10 more
semanticscholar   +1 more source