Results 21 to 30 of about 227 (71)

The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model [PDF]

European Journal of Pharmacology, 2020
Shakir D Alsharari, Wisam Toma, Hafiz Majid Mahmood   +2 more
exaly   +2 more sources

Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors [PDF]

Biochemical Pharmacology, 2020
Peter N Huynh, Peta J Harvey, Joanna Gajewiak   +2 more
exaly   +2 more sources

Molecular Interaction of α-Conotoxin RgIA with the Rat α9α10 Nicotinic Acetylcholine Receptor [PDF]

Molecular Pharmacology, 2015
Layla Azam, Athanasios Papakyriakou, Marios Zouridakis   +2 more
exaly   +2 more sources

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α‐conotoxin RgIA [PDF]

Journal of Neurochemistry, 2012
Layla Azam, J Michael Mcintosh
exaly   +2 more sources

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement [PDF]

Pain, 2014
Lorenzo Di Cesare Mannelli, Lorenzo Cinci, Laura Micheli   +2 more
exaly   +2 more sources

Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors

Frontiers in Pharmacology, 2022
In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor.
Arik J. Hone, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +4 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

British Journal of Pharmacology, Volume 178, Issue S1, Page S157-S245, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Alistair Mathie, John A Peters, Emma L Veale, Jörg Striessnig, Eamonn Kelly, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Richard W. Aldrich, Bernard Attali, Austin M Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, William A. Catterall, Alex C. Conner, Paul Davies, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Chandy George, Steve A. N. Goldstein, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Mike Jarvis, Anders A. Jensen, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Joseph W. Lynch, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Lixia Yue, Xiaoli Zhang, Michael Zhu   +57 more
wiley   +1 more source

α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors

Marine Drugs, 2020
Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a
Alexey V. Osipov, Tatiana I. Terpinskaya, Tatsiana Yanchanka, Tatjana Balashevich, Maxim N. Zhmak, Victor I. Tsetlin, Yuri N. Utkin   +6 more
doaj   +1 more source

HF‐Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

Angewandte Chemie, Volume 128, Issue 42, Page 13368-13373, October 10, 2016., 2016
Boc‐Synthese leicht gemacht: Peptidthioester können durch Boc‐Chemie über eine Kombination von milder Säureentschützung (Trifluoressigsäure/Trimethylsilylbromid) und Merrifield‐Harz direkt synthetisiert werden. Das Verfahren wurde auf die Synthese von cyclischen Peptiden und ein phosphoryliertes Protein angewendet.
Richard Raz, Fabienne Burlina, Mohamed Ismail, Julian Downward, Jiejin Li, Stephen J. Smerdon, Martin Quibell, Peter D. White, John Offer   +8 more
wiley   +2 more sources