Results 61 to 70 of about 918,188 (129)

α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t [PDF]

, 2017
Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD) spectroscopy and mass spectrometry (MS) were used to assess the effect of each chemical ...
Owen M. McDougal, Cort, John R., Owen McDougal, Matthew Turner, McDougal, Owen M., John Cort, John R. Cort, Matthew W. Turner, Turner, Matthew W.   +8 more
core   +1 more source

NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold

, 2006
We have determined a high-resolution three-dimensional structure of α-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout α-conotoxin BuIA exhibits strong antagonistic activity at α6 ...
Do-heyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

NMR solution conformation of and antitoxic analogue of α-conotoxin GI: identification of a common nicotinic acetylcholine receptor α₁-subunit binding surface for small ligans and α-conotoxins

, 1999
The three-dimensional solution conformation of an 11-residue antitoxic analogue of α-conotoxin GI, des-Glu1-[Cys3Ala]-des-Cys13-conotoxin GI (CANPACGRHYS-NH2, designated 'GI-15' henceforth), has been determined using two-dimensional 1H NMR spectroscopy ...
K Hun Mok, Kyou Hoon Han
core   +1 more source

α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor [PDF]

, 2019
The potency and selectivity of conotoxin peptides for neuropathic receptors has made them attractive lead compounds in the development of new therapeutics.
Knuhtsen, Astrid, Whitmore, Charlotte, Jamieson, Andrew G., Kinnear, Kenneth I., McWhinnie, Fergus S., Green, A. Christopher, McDougall, Laura, Timperley, Christopher M., Whiting, Rachel, Smith, Brian O.   +9 more
core   +1 more source

Odor and chemesthesis from brief exposure to TXIB

, 2005
An experiment explored ability of subjects to detect vapors of the plasticizer TXIB (2,2,4-trimethyl-1,3-pentanediol diisobutyrate) and ethanol via olfaction and via ocular and nasal chemesthesis, i.e. chemically stimulated feel. Testing, tailored to the
Pilla Caminha, G., Cain, W.S., Schmidt, R., de Wijk, R.A., Jalowayski, A.A.   +4 more
core   +1 more source

α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors

, 2003
Until now, there have been no antagonists to discriminate between heteromeric nicotinic acetylcholine receptors (nAChRs) containing the very closely related α6 and α3 subunits. nAChRs containing α3, α4, or α6 subunits in combination with β2, occasionally
Baldomero M. Olivera, Doju Yoshikami, Cheryl Dowell, Maren Watkins, Alexander Kuryatov, James E. Garrett, Sarah T. Staheli, Jon M. Lindstrom, J. Michael McIntosh   +8 more
core   +1 more source

Characterization of an α 4/7-Conotoxin LvIF from Conus lividus That Selectively Blocks α3β2 Nicotinic Acetylcholine Receptor. [PDF]

Mar Drugs, 2021
Guo M, Yu J, Zhu X, Zhangsun D, Luo S.
europepmc   +1 more source

Cryo-EM Structure of a Triazole α-Conotoxin GI Mimetic Bound to the Muscle-Type Nicotinic Acetylcholine Receptor

bioRxiv
Disulfide-rich peptides possess exceptional potency and selectivity but are often limited by the instability and synthetic challenges associated with native disulfide bonds.
Oscar A. Shepperson, Michael J. Capper, Charlie Holdship, Oliver J. Melling, Nicola Wade, Michael A. Malone, Kirsty I. M. Arnott, Danielle C. Morgan, T. Piggot, T. Morcom, Josephine A. Connah, Leonie M. Windeln, C. Timperley, J. Frey, A. C. Green, J. Koehnke, J. Essex, Andrew G. Jamieson   +17 more
semanticscholar   +1 more source

Optimizing the connectivity in disulfide-rich peptides: α-conotoxin SII as a case study

, 2005
We describe a strategy for the efficient, unambiguous assignment of disulfide connectivities in α-conotoxin SII, of which ∼30% of its mass is cysteine, as an example of a generalizable technique for investigation of cysteine-rich peptides.
Livett, Bruce G., Broxton, Natalie M., Moczydlowski, Edward G., Jones, Alun, Down, John G., Bingham, Jon-Paul   +5 more
core   +1 more source

Discovery of Novel Antinociceptive α‑Conotoxin Analogues from the Direct In Vivo Screening of a Synthetic Mixture-Based Combinatorial Library

, 2016
Marine cone snail venoms consist of large, naturally occurring combinatorial libraries of disulfide-constrained peptide neurotoxins known as conotoxins, which have profound potential in the development of analgesics.
Shainnel O. Eans (1375899), Elisa Mizrachi (1577218), Kate J. Reilley (1983916), Michelle R. Hoot (1983919), Reena Gyanda (1983907), Richard A. Houghten (381453), Christopher J. Armishaw (1983910), Jayati Banerjee (1983913), Michelle L. Ganno (1375911), Jay P. McLaughlin (1375902)   +9 more
core   +1 more source