Results 51 to 60 of about 918,188 (129)

α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

, 1998
Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally ...
Siqin Luo, G. Edward Cartier, Jennifer M. Kulak, Doju Yoshikami, Baldomero M. Olivera, Richard B. Jacobsen, J. Michael McIntosh   +6 more
core   +1 more source

Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the α₁/δ subunit interface of Torpedo nicotinic acetylcholine receptor

, 2001
A high resolution structure of α-conotoxin EI has been determined by 1H NMR spectroscopy and molecular modeling. α-Conotoxin EI has the same disulfide framework as α4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the ...
Jae Eun Suk, Kyou Hoon Han, Kyu Hwan Park, J Michael McIntosh, Richard Jacobsen, William R Gray   +5 more
core   +1 more source

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Marine Drugs
α-Conotoxins (α-CTxs) are structurally related peptides that antagonize nicotinic acetylcholine receptors (nAChRs), which may serve as new alternatives to opioid-based treatment for pain-related conditions.
Tian-Miao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, D. J. Adams, Rilei Yu   +7 more
semanticscholar   +1 more source

α-RgIA: A novel conotoxin that specifically and potently blocks the α9α10 nAChR

, 2006
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits assemble to form the α9α10 nAChR subtype. This receptor is believed to mediate cholinergic synaptic transmission between efferent olivocochlear fibers and the hair cells of the cochlea.
McIntosh, J. Michael, Watkins, Maren, Elgoyhen, Ana Belen, Haberlandt, Christian, Gomez Casati, Maria Eugenia, Ellison, Michael, Olivera, Baldomero M.   +6 more
core   +1 more source

Enhancing Stability and Albumin Binding Efficiency of α‑Conotoxin GI through Fatty Acid Modification

α-Conotoxin GI is a competitive blocker of muscle-type acetylcholine receptors and holds the potential for being developed as a molecular probe or a lead compound for drug discovery.
Quankuo He (17398282), Jianying Dong (14979244), Yuanyuan Lian (8364879), Panpan Qi (3255048), Junjie Zhang (355622), Sulan Luo (277905), Ting Xie (191025), Dongting Zhangsun (277907), Yong Wu (165587)   +8 more
core   +1 more source

α-Conotoxin MII Blocks Nicotine-Stimulated Dopamine Release in Rat Striatal Synaptosomes

, 1997
Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS.
Jennifer M. Kulak, Baldomero M. Olivera, Thu A. Nguyen, J. Michael McIntosh   +3 more
core   +1 more source

Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-Conotoxin GIC [PDF]

, 2012
Nicotinic acetylcholine receptors (nAChRs) are a diverse familyof homo- or heteropentameric ligand-gated ion channels.Understanding the physiological role of each nAChR subtypeand the key residues responsible for normal and pathologicalstates is ...
Do-Hyoung Kim, D H Kim, Kyou Hoon Han, Si-Hyung Lee, Si Hyoung Lee, Chewook Lee, Kyou-Hoon Han   +6 more
core   +1 more source

Structural Basis for α-Conotoxin Potency and Selectivity [PDF]

, 2009
Parkinson\u27s disease is a debilitating movement disorder characterized by altered levels of α6β2* nicotinic acetylcholine receptors (nAChRs) localized on presynaptic striatal catecholaminergic neurons.
Narver, Andrew, Eidemiller, Seth, McDougal, Owen M., Turner, Matthew, Martin, Bryan, Marshall, Joshua, Cornell, Kenneth A.   +6 more
core   +1 more source

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor

, 2021
Conotoxins are marine peptide toxins from marine cone snails. The α-conotoxin RegIIA can selectively act on human (h) α3β4 nicotinic acetylcholine receptor (nAChR), and is an important lead for drug development.
Liang Xue (174224), Tao Jiang (28401), Han Shen Tae (20023188), Rilei Yu (228408), Meiling Zheng (4610461)   +4 more
core   +1 more source

α-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as α3β2 and α7 nicotinic acetylcholine receptors

, 2006
The molluskan acetylcholine-binding protein (AChBP) is a homolog of the extracellular binding domain of the pentameric ligand-gated ion channel family. AChBP most closely resembles the α-subunit of nicotinic acetylcholine receptors and in particular the ...
I Tsigelny, K Y Ho, Kyou Hoon Han, C Dowell, T T Talley, J M McIntosh, S B Christensen, B M Olivera, P Taylor   +8 more
core   +1 more source