Results 41 to 50 of about 918,188 (129)

GABAB Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell‐Derived Sensory Neurons by Baclofen and α‐Conotoxin Vc1.1

Journal of Neurochemistry
GABAB receptor (GABABR) activation is known to alleviate pain by reducing neuronal excitability, primarily through inhibition of high voltage‐activated (HVA) calcium (CaV2.2) channels and potentiating G protein–coupled inwardly rectifying potassium (GIRK)
Mitchell St Clair-Glover, Arsalan Yousuf, Dominic Kaul, M. Dottori, D. J. Adams   +4 more
semanticscholar   +1 more source

Structure and Activity of (2,8)-Dicarba-(3,12)-cystino α-ImI, an α-Conotoxin Containing a Nonreducible Cystine Analogue

, 2016
The α-conotoxins are potent and selective antagonists of nicotinic acetylcholine receptors (nAChR). Exploitation of these and other peptides in research and clinical settings has been hampered by the lability of the disulfide bridges that are essential ...
Jayamini Illesinghe (2392780), Andrea J. Robinson (1528231), Raymond S. Norton (221364), Bianca J. van Lierop (1705615), Amanda L. Townsend (2392777), Bruce G. Livett (2392783), Christopher A. MacRaild (649150), Mary Chebib (509902)   +7 more
core   +1 more source

Engineering Enhanced Antimicrobial Properties in α-Conotoxin RgIA through D-Type Amino Acid Substitution and Incorporation of Lysine and Leucine Residues

Molecules
Antimicrobial peptides (AMPs), acknowledged as host defense peptides, constitute a category of predominant cationic peptides prevalent in diverse life forms. This study explored the antibacterial activity of α-conotoxin RgIA, and to enhance its stability
Ming-He Wang, Zhouyuji Liao, Dong-Ting Zhangsun, Yong Wu, Su-Lan Luo   +4 more
semanticscholar   +1 more source

Nuclear magnetic resonance solution conformation of α-conotoxin AuIB, an α3β4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist

, 2000
The neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of α and β subunits, α-Conotoxins are a homologous series of small peptides that antagonize these receptors.
K Hun Mok, Baldomero M Olivera, Kyou Hoon Han, Kyu Hwan Park, J Michael McIntosh, Jee Hyun Cho   +5 more
core   +1 more source

Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain

Marine Drugs
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized,
Hongyu Shan, Nan Wang, Xin-Yu Gao, Zihan Wang, Jin-Peng Yu, Dong-Ting Zhangsun, Xiao-Peng Zhu, Su-Lan Luo   +7 more
semanticscholar   +1 more source

Nuclear magnetic resonance solution conformation of α-conotoxin AuIB, an α3ß4 subtype-selective neuronal nicotinic acetylcholine receptor antagonist [PDF]

, 2000
journal articleThe neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of α and ß subunits.
Cho, Jee-Hyun; Mok, K. Hun; Park, Kyu-Hwan; Han, Kyou-Hoon, Olivera, Baldomero M.; McIntosh, J. Michael   +1 more
core  

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors

, 2015
Covalently attached peptide dendrimers can enhance binding affinity and functional activity. Homogenous di- and tetravalent dendrimers incorporating the α7-nicotinic receptor blocker α-conotoxin ImI (α-ImI) with polyethylene glycol spacers were designed ...
Adams, David J., David J. Adams (119198), Alewood, Paul F., Jingjing Wan (1639792), Blessy Paul (1639783), Wan, Jingjing, Joshua Lawson (1639789), Abraham, Nikita, Lawson, Joshua, Vetter, Irina, Mobli, Mehdi, Paul, Blessy, Lewis, Richard J., Nikita Abraham (1639795), Paul F. Alewood (1520788), Richard J. Lewis (30801), Han-Shen Tae (1639798), Huang, Johnny X., Irina Vetter (394252), Matthew A. Cooper (216663), Johnny X. Huang (1639786), Mehdi Mobli (233174), Cooper, Matthew A., Tae, Han-Shen   +23 more
core   +1 more source

Single Amino Acid Substitution in Loop1 Switches the Selectivity of α-Conotoxin RegIIA towards the α7 Nicotinic Acetylcholine Receptor

Marine Drugs
α-Conotoxins are disulfide-rich peptides obtained from the venom of cone snails, which are considered potential molecular probes and drug leads for nAChR-related disorders.
Jin-Peng Yu, Jun-Jie Xie, Yuting Ma, Pengcheng Wei, Pan-Pan Zhang, Zepei Tang, Xiao-Peng Zhu, Dong-Ting Zhangsun, Su-Lan Luo   +8 more
semanticscholar   +1 more source

Interactions between the presynaptically active neurotoxins α-latrotoxin and ω-conotoxin GVIA: studies on calcium fluxes and binding parameters in rat and chicken synaptosomes

, 1990
Possible interactions between α-latrotoxin, an activator of synaptosomal calcium uptake, and ω-conotoxin GVIA, an inhibitor of voltage-sensitive calcium channels of the N-type, were investigated in rat and chicken synaptosomal preparations.
H. W. Scheer
core   +1 more source

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Marine Drugs
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl D. Dowell, Arik J. Hone, David Morgenstern, Victor M. Chua, I. B. L. Ramiro, J. Imperial, Lee S. Leavitt, J. Phan, Fernando A. Fisher, M. Watkins, Shrinivasan Raghuraman, Jortan O. Tun, Beatrix M. Ueberheide, J. M. McIntosh, V. Vasconcelos, B. M. Olivera, J. Gajewiak   +19 more
semanticscholar   +1 more source