Results 31 to 40 of about 918,188 (129)

Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI

Toxins, 2022
Conotoxins (CTXs) are a variety of mixed polypeptide toxins, among which α-conotoxin MI (CTX-MI) is the most toxic. Serious toxic symptoms, a lack of counteracting drugs, and cumbersome detection processes have made CTX-MI a hidden danger for humans. One
Han Guo, Bowen Deng, Luming Zhao, Yun Gao, Xiaojuan Zhang, Chengfang Yang, B. Zou, Han Chen, Mingjuan Sun, Lianghua Wang, Bing-Hua Jiao   +10 more
semanticscholar   +1 more source

Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors

, 2004
α-Conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. α-Conotoxin GIC potently blocks the α3β2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [
Do-Hyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

, 2016
The two disulfide bonds of α-conotoxin ImI, a peptide antagonist of the α7 nicotinic acetylcholine receptor (nAChR), were systematically replaced with isosteric redox-stable cystathionine thioethers. Regioselective thioether formation was accomplished on
Paul F. Alewood (1520788), Norelle L. Daly (457317), Richard J. Lewis (30801), Irina Vetter (394252), David J. Craik (13753), Zoltan Dekan (2161108)   +5 more
core   +2 more sources

Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus

International Journal of Molecular Sciences, 2022
The marine cone snail produces one of the fastest prey strikes in the animal kingdom. It injects highly efficacious venom, often causing prey paralysis and death within seconds.
Sean Wiere, Christopher K. Sugai, M. Espiritu, Vincent P. Aurelio, C. D. Reyes, Nicole Yuzon, R. Whittal, J. Tytgat, S. Peigneur, J. Bingham   +9 more
semanticscholar   +1 more source

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

Frontiers in Pharmacology, 2022
A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized.
Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Meng-qing Yang, Rilei Yu, W. Du, David John Adams, Qiuyun Dai   +15 more
semanticscholar   +1 more source

Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes

, 2006
α-Conotoxin OmIA from Conus omaria is the only α-conotoxin that shows a ∼20-fold higher affinity to the α3β2 over the α6β2 subtype of nicotinic acetylcholine receptor.
Do-heyoung Kim, Seung-Wook Chi, Kyou Hoon Han, J M McIntosh, B M Olivera   +4 more
core   +1 more source

A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABABR-Coupled N-Type Calcium Channel

Marine Drugs, 2022
α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABABR)-coupled N-type calcium channel (CaV2.2).
Yuanmei Wei, M. Zhang, Shuo Yu, QiuYuan Huang, R. Chen, Shu-Jing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai   +9 more
semanticscholar   +1 more source

Stability and Structure-Forming Properties of the Two Disulfide Bonds of α-Conotoxin GI

, 2016
α-Conotoxin GI is a 13 residue snail toxin peptide cross-linked by Cys2−Cys7 and Cys3−Cys13 disulfide bridges. The formation of the two disulfide bonds by thiol/disulfide exchange with oxidized glutathione (GSSG) has been characterized.
Andreas Kaerner (2140825), Dallas L. Rabenstein (1954081)   +1 more
core   +1 more source

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
McIntosh, J. Michael, Baldomero M. Olivera, Paola V. Plazas, Maren Watkins, Watkins, Maren, Elgoyhen, Ana Belen, María E. Gomez-Casati, Gomez Casati, Maria Eugenia, Plazas, Paola Viviana, Olivera, Baldomero M., J. Michael McIntosh, A. Belén Elgoyhen   +11 more
core   +1 more source

Differential contributions of CaV2.2, GIRK, and HCN channel to the modulation of excitability by α-conotoxin Vc1.1 and baclofen in somatic and visceral sensory neurons

bioRxiv
Chronic visceral pain is a key symptom of irritable bowel syndrome (IBS). Modulation of voltage-dependent calcium and potassium channels by G protein-coupled receptors (GPCRs) plays a key role in dampening nociceptive transmission.
Mariana Brizuela, Anuja R. Bony, S. Garcia Caraballo, D. J. Adams, Stuart M. Brierley   +4 more
semanticscholar   +1 more source