Results 21 to 30 of about 918,188 (129)
The FASEB Journal, 2023 This study was undertaken to identify and characterize the first ligands capable of selectively identifying nicotinic acetylcholine receptors containing α7 and β2 subunits (α7β2‐nAChR subtype). Basal forebrain cholinergic neurons express α7β2‐nAChR. Here,
Andrew A. George +12 more
semanticscholar +1 more source
Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli. [PDF]
Mar Drugs, 2016 α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Zhu X +6 more
europepmc +2 more sources
Protein Expression and Purification, 2023 α-Conotoxin ImI is a selective antagonist of alpha7 nicotinic acetylcholine receptor (α7 nAChR) that is involved in cancer development. Human alpha fetoprotein domain 3 (AFP3) is a prototype of anticancer agents.
Xiaobing Chen +8 more
semanticscholar +1 more source
ACS Chemical Neuroscience, 2023 Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic acetylcholine receptor (nAChR) subtypes is a prerequisite for the design of tool compounds to study nAChRs.
Yves Haufe +12 more
semanticscholar +1 more source
Head-to-Tail Cyclization of α-Conotoxin TxID Leads to Enhanced Stability in Serum
GAZI UNIVERSITY JOURNAL OF SCIENCE, 2023 Peptide biomolecules have important bioactivities and hence their use in drug design and development studies has increased in recent years. Conotoxins are natural peptides that obtained from cone snail venoms and have the potential to be used for chronic
Nurcan Biçen Karakoç, M. Akcan
semanticscholar +1 more source
Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor
, 2017 Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been used as pharmacological probes and investigated as drug leads for nAChR ...
Paul F. Alewood +5 more
core +2 more sources
Prey specificity of predatory venoms
Biological Reviews, Volume 99, Issue 6, Page 2253-2273, December 2024.ABSTRACT Venom represents a key adaptation of many venomous predators, allowing them to immobilise prey quickly through chemical rather than physical warfare. Evolutionary arms races between prey and a predator are believed to be the main factor influencing the potency and composition of predatory venoms.
Ondřej Michálek +2 more
wiley +1 more source
Solution Structure and Acid-Base Properties of Reduced α-Conotoxin MI [PDF]
, 2021 The reduced derivative of α-conotoxin MI, a 14 amino acid peptide is characterized by NMR-pH titrations and molecular dynamics simulations to determine the protonation constants of the nine basic moieties, including four cysteine thiolates, and the ...
Pálla, Tamás +13 more
core +1 more source
Journal of Medicinal Chemistry, 2022 α-Conotoxins (α-CTxs) can selectively target nicotinic acetylcholine receptors (nAChRs) and are important drug leads for the treatment of cancer, chronic pain, and neuralgia. Here, we chemically synthesized a formerly defined rat α7 nAChR targeting α-CTx
Jiazhen Liang +8 more
semanticscholar +1 more source
α-Conotoxin Peptidomimetics:Probing the Minimal Binding Motif for Effective Analgesia [PDF]
, 2020 Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets-nicotinic acetylcholine and γ-aminobutyric acid ...
Belgi, Alessia +11 more
core +1 more source