Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB [PDF]
Marine Drugs, 2021 α-Conotoxin TxIB, a selective antagonist of α6/α3β2β3 nicotinic acetylcholine receptor, could be a potential therapeutic agent for addiction and Parkinson’s disease.
Dongting Zhangsun, Sulan Luo, Shuai Dong
exaly +5 more sources
Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB [PDF]
Marine Drugs, 2020 α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs.
Dongting Zhangsun +2 more
exaly +5 more sources
Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide [PDF]
Marine Drugs, 2013 Alpha6beta2 nicotinic acetylcholine receptors (nAChRs) are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including addiction and Parkinson’s disease.
Dongting Zhangsun, Xiaosa Wu, Sulan Luo
exaly +5 more sources
α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice [PDF]
Marine Drugs, 2019 α-Conotoxin TxIB is a specific antagonist of α6/α3β2β3(α6β2*) nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM.
Dongting Zhangsun +2 more
exaly +5 more sources
α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice [PDF]
Marine DrugsNicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects.
Sulan Luo, Jiaolin Bao, Meiting Wang
exaly +5 more sources
α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal [PDF]
Frontiers in Pharmacology, 2022 Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao +8 more
doaj +3 more sources
α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors [PDF]
Frontiers in Pharmacology, 2021 Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the ...
Xiaodan Li +6 more
doaj +3 more sources
Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors [PDF]
International Journal of Molecular Sciences, 2023 Conotoxins are widely distributed and important for studying ligand-gated ion channels. TxIB, a conotoxin consisting of 16 amino acids derived from Conus textile, is a unique selective ligand that blocks rat α6/α3β2β3 nAChR (IC50 = 28 nM) without ...
Dongting Zhangsun +2 more
exaly +3 more sources
Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID. [PDF]
Mar Drugs, 2023 α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Dong J +7 more
europepmc +2 more sources
Cyclization of the Analgesic α-Conotoxin Vc1.1 With a Non-Natural Linker: Effects on Structure, Stability, and Bioactivity. [PDF]
J Pept Sciα‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain. Backbone cyclization was applied to enhance its drug‐like properties, resulting in improved serum stability and oral bioavailability ...
Zhang Y +4 more
europepmc +2 more sources