Results 1 to 10 of about 38 (26)

Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB

Marine Drugs, 2021
α-Conotoxin TxIB, a selective antagonist of α6/α3β2β3 nicotinic acetylcholine receptor, could be a potential therapeutic agent for addiction and Parkinson’s disease.
Baojian Zhang, Dongting Zhangsun, Shuai Dong   +2 more
exaly   +4 more sources

Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB

Marine Drugs, 2020
α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs.
Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +2 more
exaly   +4 more sources

Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide

Marine Drugs, 2013
Alpha6beta2 nicotinic acetylcholine receptors (nAChRs) are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including addiction and Parkinson’s disease.
Xiaosa Wu, Dongting Zhangsun, Sulan Luo   +2 more
exaly   +4 more sources

α-Conotoxin TxIB: A Uniquely Selective Ligand for α6/α3β2β3 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Conditioned Place Preference in Mice

Marine Drugs, 2019
α-Conotoxin TxIB is a specific antagonist of α6/α3β2β3(α6β2*) nicotinic acetylcholine receptor (nAChR) with an IC50 of 28 nM.
Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo   +2 more
exaly   +4 more sources

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice

Marine Drugs
Nicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects.
Jiaolin Bao, Dongting Zhangsun, Sulan Luo   +2 more
exaly   +4 more sources

α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology, 2021
Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the ...
Baojian Zhang, Dongting Zhangsun, Sulan Luo   +2 more
exaly   +3 more sources

α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal

Frontiers in Pharmacology, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Kailin Mao, Xiaoqian Dong, Dongting Zhangsun   +2 more
exaly   +3 more sources

DataSheet2_α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal.docx

, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Zongde Chen (12026525), Xiaodan Li (132227), Xiaoqian Dong (10977315), Sulan Luo (277905), Kailin Mao (12026522), Dongting Zhangsun (277907), Xiaopeng Zhu (16758)   +6 more
core   +1 more source

DataSheet1_α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal.docx

, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Zongde Chen (12026525), Xiaodan Li (132227), Xiaoqian Dong (10977315), Sulan Luo (277905), Kailin Mao (12026522), Dongting Zhangsun (277907), Xiaopeng Zhu (16758)   +6 more
core   +1 more source

Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors

, 2023
Conotoxins are widely distributed and important for studying ligand-gated ion channels. TxIB, a conotoxin consisting of 16 amino acids derived from Conus textile, is a unique selective ligand that blocks rat α6/α3β2β3 nAChR (IC50 ...
Jinpeng Yu, Jinyuan Zhao, Panpan Qi, Ting Xie, Xiaopeng Zhu, Sulan Luo, Jianying Dong, Panpan Zhang, Yuan Qin, Dongting Zhangsun   +9 more
core   +1 more source