Results 11 to 20 of about 918,188 (129)

Stapling Cysteine[2,4] Disulfide Bond of α-Conotoxin LsIA and Its Potential in Target Delivery. [PDF]

Mar Drugs
α-Conotoxins, as selective nAChR antagonists, can be valuable tools for targeted drug delivery and fluorescent labeling, while conotoxin-drug or conotoxin-fluorescent conjugates through the disulfide bond are rarely reported.
Sun X, Hu J, Ren M, Chang H, Zhangsun D, Zhang B, Dong S.   +6 more
europepmc   +3 more sources

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity. [PDF]

Front Pharmacol
Background and Purpose Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions.
Wang W, Wang M, Wang H, Xu W, Wang C, Pei J, Li X, Zhangsun D.   +7 more
europepmc   +2 more sources

Fluorescently Labeled α-Conotoxin TxID, a New Probe for α3β4 Neuronal Nicotinic Acetylcholine Receptors. [PDF]

Mar Drugs, 2022
Neuronal nicotinic acetylcholine receptors (nAChRs) are important ion channel membrane proteins that are widely distributed in the central nervous system (CNS) and peripheral nervous system (PNS).
Huang M, Zhu X, Yang Y, Tan Y, Luo S, Zhangsun D.   +5 more
europepmc   +2 more sources

Characterization of a Novel α-Conotoxin from Conus textile That Selectively Targets α6/α3β2β3 Nicotinic Acetylcholine Receptors* [PDF]

Journal of Biological Chemistry, 2013
Dongting Zhangsun, Xiaopeng Zhu, J Michael McIntosh   +2 more
exaly   +2 more sources

DataSheet2_α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal.docx

, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Zongde Chen (12026525), Xiaodan Li (132227), Xiaoqian Dong (10977315), Sulan Luo (277905), Kailin Mao (12026522), Dongting Zhangsun (277907), Xiaopeng Zhu (16758)   +6 more
core   +1 more source

DataSheet1_α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal.docx

, 2022
Background and Purpose: Alcohol use disorder (AUD) is a serious public health issue and affects the lives of numerous people. Previous studies have shown a link between nicotinic acetylcholine receptors (nAChR) and alcohol addiction. However, the role of
Zongde Chen (12026525), Xiaodan Li (132227), Xiaoqian Dong (10977315), Sulan Luo (277905), Kailin Mao (12026522), Dongting Zhangsun (277907), Xiaopeng Zhu (16758)   +6 more
core   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, van Elk, René, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Buttner, R., Elk, R. van, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R.   +46 more
core   +1 more source

Solution structure of α-conotoxin SI [PDF]

, 2000
The nuclear magnetic resonance solution structure of α-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that α-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds ...
Hargittai, Balazs, Balazs Hargittai, Benie, Andrew J., Robert W. Janes, Andrew J. Benie, Janes, Robert W., George Barany, Barany, George, David Whitford, Whitford, David   +9 more
core   +1 more source

Ion Channels as Marine Drug Targets [PDF]

, 2020
Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr.

core   +2 more sources

Characterization of a Novel α-Conotoxin from Conus textile That Selectively Targets α6/α3β2β3 Nicotinic Acetylcholine Receptors*

Journal of Biological Chemistry, 2012
Background: Cone snails are a rich source of α-conotoxins that target nicotinic acetylcholine receptors (nAChR). Results: A new α-conotoxin TxIB potently blocked α6/α3β2β3 nAChRs with high selectivity.
Su-Lan Luo, Dong-Ting Zhangsun, Yong Wu, Xiao-Peng Zhu, Yuan-Yan Hu, M. McIntyre, S. Christensen, M. Akcan, D. Craik, J. M. McIntosh   +9 more
semanticscholar   +1 more source